Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL.
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL.
Semin Perinatol. 2018 Apr;42(3):149-154. doi: 10.1053/j.semperi.2018.02.002. Epub 2018 Mar 2.
Each year, thousands of children are born with or develop permanent disabilities such as hearing loss, vision loss, motor and cognitive deficits from congenital CMV infection (cCMV). However, awareness of cCMV and its associated sequelae is very low in pregnant women and healthcare providers. Both targeted and universal approaches to screen newborns for CMV infection are now achievable due to recent scientific advances including the development of a rapid, high-throughput method for detecting CMV in saliva, the efficacy of antiviral treatment in symptomatic infants, and the demonstration of cost effectiveness of CMV screening. Future studies are needed to address gaps in our understanding on the role of non-primary maternal CMV infections, the evaluation of antiviral treatment in asymptomatic infants, and the implementation of prevention strategies for cCMV.
每年都有数千名儿童出生时或在成长过程中患有永久性残疾，如听力损失、视力损失、运动和认知缺陷等，这些都是由先天性 CMV 感染（cCMV）引起的。然而，孕妇和医疗保健提供者对 cCMV 及其相关后遗症的认识非常低。由于最近的科学进步，包括开发快速、高通量的唾液中 CMV 检测方法、抗病毒治疗对有症状婴儿的疗效以及 CMV 筛查的成本效益证明，现在可以实现针对新生儿 CMV 感染的靶向和普遍筛查方法。未来的研究需要解决我们对非原发性母体 CMV 感染作用、无症状婴儿抗病毒治疗评估以及 cCMV 预防策略实施方面理解的差距。
