Goldwater P N, Woodfield D G, Ramirez A M, Anzimlt I S
N Z Med J. 1986 Sep 24;99(810):703-5.
Seventy-five of 88 (85.2%) vaccinees seroconverted at three months after three 2 micrograms doses of a plasma-derived hepatitis B vaccine had been given intradermally one month apart. Vaccinees under 30 years of age had a significantly better seroconversion rate (88.8%) than older subjects (50%) as measured at three months. Forty-three of 47 (91%) vaccinees who were bled one year post vaccination had antibody levels in excess of 10 IU/1. This study indicates that short course, low dose, intradermal vaccination with plasma-derived hepatitis B vaccine may be a viable and cheap regimen for inducing immunity against hepatitis B in younger subjects.
在间隔1个月皮内注射3剂2微克血浆源性乙肝疫苗后，88名接种者中有75名（85.2%）在3个月时出现血清转化。3个月时检测发现，30岁以下的接种者血清转化率（88.8%）显著高于年长接种者（50%）。47名接种者在接种疫苗1年后采血检测，其中43名（91%）的抗体水平超过10 IU/1。本研究表明，采用血浆源性乙肝疫苗进行短疗程、低剂量皮内接种，可能是在年轻人群中诱导乙肝免疫的一种可行且廉价的方案。
