Biggee Kristin, Gale Michael J, Smith Travis B, Suhler Eric B, Pennesi Mark E, Lin Phoebe
Kaiser Medical Group Salmon Creek, 14406 NE 20th Ave, Vancouver, WA 98686, USA.
Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA.
Am J Ophthalmol Case Rep. 2016 Mar 11;1:16-22. doi: 10.1016/j.ajoc.2016.03.001. eCollection 2016 Apr.
To determine if adaptive optics (AO) flood illumination imaging can detect subclinical changes in 4 cases of posterior uveitis affecting the outer retina.
In all 4 cases, the affected eye showed altered areas in the photoreceptor mosaic on AO that corresponded to changes on other imaging modalities. Abnormalities not apparent on other imaging modalities were also noted. In one case of multifocal choroiditis with acute outer retinal atrophy, AO revealed decreased visualization of photoreceptors in the unaffected eye that was not noted on spectral domain-optical coherence tomography. In the patient with multiple evanescent white dot syndrome, focal photoreceptor abnormalities were more apparent on AO compared to other imaging modalities, and these areas normalized on AO during follow-up. Five weeks after initiation of high dose prednisone and azathioprine in a patient with serpiginous choroidopathy, AO images showed recovery in apparent parafoveal cone density.
AO detects subclinical changes in the photoreceptor layer in posterior uveitis that can recover over time. AO may be useful in following outer retinal inflammatory conditions.
确定自适应光学（AO）泛光照明成像能否检测4例累及外层视网膜的后葡萄膜炎的亚临床变化。
在所有4例病例中，患眼在AO检查时显示光感受器镶嵌结构的改变区域，与其他成像方式上的变化相对应。还注意到在其他成像方式上不明显的异常。在1例多灶性脉络膜炎伴急性外层视网膜萎缩患者中，AO显示未受影响眼的光感受器可视化程度降低，这在光谱域光学相干断层扫描中未被发现。在多灶性一过性白点综合征患者中，与其他成像方式相比，局灶性光感受器异常在AO检查时更明显，且在随访期间这些区域在AO图像上恢复正常。在匐行性脉络膜病变患者开始使用高剂量泼尼松和硫唑嘌呤5周后，AO图像显示黄斑旁视锥细胞密度明显恢复。
AO可检测后葡萄膜炎光感受器层的亚临床变化，这些变化可随时间恢复。AO可能有助于监测外层视网膜炎症情况。
