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在产前和产后个体发育过程中暴露于内分泌干扰物二氯二苯三氯乙烷（DDT）的大鼠肾上腺皮质中，经典β-连环蛋白/ Wnt信号激活的变化。

Changes in Canonical β-Catenin/Wnt Signaling Activation in the Adrenal Cortex of Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Prenatal and Postnatal Ontogeny.

作者信息

Tsomartova D A, Yaglova N V, Yaglov V V

机构信息

Research Institute of Human Morphology, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2018 Mar;164(4):493-496. doi: 10.1007/s10517-018-4019-8. Epub 2018 Mar 5.

DOI:10.1007/s10517-018-4019-8
PMID:29504097
Abstract

Prenatal and postnatal exposure to low doses of the endocrine disruptor dichlorodiphenyltrichloroethane (DDT) leads to delayed activation of the canonical β-catenin/Wnt signaling in zona glomerulosa and zona reticularis of the adrenal cortex in rats, which changed the rate of their postnatal development. Suppression of the Wnt pathway in zona fasciculata promotes its regeneration after DDT-induced blood circulation disorders and cell death.

摘要

产前和产后暴露于低剂量内分泌干扰物滴滴涕（DDT）会导致大鼠肾上腺皮质球状带和网状带中经典β-连环蛋白/Wnt信号的激活延迟，这改变了它们出生后的发育速度。束状带中Wnt通路的抑制促进了DDT诱导的血液循环紊乱和细胞死亡后的再生。

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Changes in Canonical β-Catenin/Wnt Signaling Activation in the Adrenal Cortex of Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Prenatal and Postnatal Ontogeny.在产前和产后个体发育过程中暴露于内分泌干扰物二氯二苯三氯乙烷（DDT）的大鼠肾上腺皮质中，经典β-连环蛋白/ Wnt信号激活的变化。
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引用本文的文献

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Horm Metab Res. 2024 Jan;56(1):78-90. doi: 10.1055/a-2198-9307. Epub 2023 Oct 26.
2
Developmental Exposure to Endocrine Disrupter DDT Interferes with Age-Related Involution of Thymus.发育过程中接触内分泌干扰物滴滴涕会干扰胸腺的衰老性萎缩。
Int J Mol Sci. 2022 Jun 15;23(12):6678. doi: 10.3390/ijms23126678.
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Dichlorodiphenyltrichloroethane and the Adrenal Gland: From Toxicity to Endocrine Disruption.二氯二苯三氯乙烷与肾上腺：从毒性到内分泌干扰
Toxics. 2021 Oct 1;9(10):243. doi: 10.3390/toxics9100243.
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