在个体发育不同时期暴露于低剂量滴滴涕的青春期大鼠肾上腺束状带细胞分泌活性的变化
Changes in Secretory Activity of Adrenal Zona Fasciculata Cells in Pubertal Rats Exposed to Low Doses of DDT in Different Periods of Ontogeny.
作者信息
Yaglova N V, Tsomartova D A, Obernikhin S S, Nazimova S V, Yaglov V V
机构信息
Laboratory of Endocrine System Development, Research Institute of Human Morphology, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2018 Dec;166(2):283-286. doi: 10.1007/s10517-018-4333-1. Epub 2018 Nov 28.
We studied secretory activity of adrenal zona fasciculata cells in pubertal rats exposed to low doses of endocrine disrupter DDT during prenatal and postnatal periods and only during postnatal period. In exposed animals, circulatory disturbances leading to degeneration and necrosis of cells as well as regeneration foci were revealed in the outer zona fasciculata. In rats exposed to DDT during the prenatal and postnatal periods, compensatory increase in secretory activity of cells due to increase in mitochondria content was noted in the inner zona fasciculata, which determined elevated serum concentration of corticosterone. In rats exposed to DDT only during the postnatal development, functional activity of zona fasciculata cells was suppressed, which attested to delayed upregulation of secretion.
我们研究了在产前和产后以及仅在产后暴露于低剂量内分泌干扰物滴滴涕（DDT）的青春期大鼠肾上腺束状带细胞的分泌活性。在暴露的动物中，在外层束状带发现了导致细胞变性和坏死以及再生灶的循环障碍。在产前和产后暴露于DDT的大鼠中，在内层束状带中观察到由于线粒体含量增加导致细胞分泌活性的代偿性增加，这导致血清皮质酮浓度升高。在仅在产后发育期间暴露于DDT的大鼠中，束状带细胞的功能活性受到抑制，这证明了分泌上调延迟。
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