Research Institute of Human Morphology, Moscow, Russia.
Bull Exp Biol Med. 2020 Jul;169(3):398-400. doi: 10.1007/s10517-020-04895-6. Epub 2020 Aug 3.
We studied histophysiology of the adrenal medulla in adult (70-day-old) male Wistar rats developmentally exposed to low doses of endocrine disruptor DDT. It was found that exposure to DDT during the prenatal and postnatal ontogeny decelerated the development of the adrenal medulla and reduced the synthesis of tyrosine hydroxylase, the rate-liming enzyme of catecholamine synthesis, in chromaffin cells, which led to a decrease in epinephrine secretion into the blood.
我们研究了发育期暴露于低剂量内分泌干扰物滴滴涕的成年（70 日龄）雄性 Wistar 大鼠肾上腺髓质的组织生理学。结果发现，产前和产后发育过程中接触滴滴涕会减缓肾上腺髓质的发育，并降低嗜铬细胞中天冬氨酸羟化酶的合成，这是儿茶酚胺合成的限速酶，导致肾上腺素分泌入血液减少。
