Zil-E-Ali Ahsan, Janjua Omer Hanif, Latif Aiza, Aadil Muhammad
Department of Surgery, Fatima Memorial Hospital, Lahore, Pakistan.
Layton Rahmatullah Benevolent Trust Hospital, Lahore, Shaikh Zayed Hospital, Lahore, Pakistan.
J Ayub Med Coll Abbottabad. 2018 Jan-Mar;30(1):121-123.
Cushing's syndrome is a collection of signs and symptoms due to hypercortisolism. Prolong use of topical steroid may cause this syndrome and suppression of hypothalamic and pituitary function, however such events are more common with oral and parenteral route. There are very few cases of Cushing's syndrome with a topical application amongst which triamcinolone is the rarest drug. We report a case of 11-year-old boy is presented who developed Cushing's disease by topical application. The child had body rashes for which the caregiver consulted a local quack, a topical cream of triamcinolone was prescribed. After application for three months, the patient became obese and developed a moon-like face. A thorough biochemical workup and diagnostic test for Cushing's disease was done to confirm. The following case report a dramatic example of development of the syndrome from chronic topical application of the least potent corticosteroid.
库欣综合征是一组由于皮质醇增多引起的体征和症状。长期使用外用类固醇可能导致该综合征以及下丘脑和垂体功能抑制，然而此类情况在口服和胃肠外途径更为常见。外用引发库欣综合征的病例非常少，其中曲安奈德是最罕见的药物。我们报告一例11岁男孩通过外用发生库欣病的病例。该患儿有皮疹，其照顾者咨询了当地庸医，开具了曲安奈德外用乳膏。用药三个月后，患者变得肥胖并出现满月脸。进行了全面的生化检查和库欣病诊断测试以确诊。以下病例报告是因长期外用效力最低的皮质类固醇导致该综合征的一个显著例子。
