Semiz Serap, Balci Yasemin Işik, Ergin Seniz, Candemir Maşallah, Polat Aziz
Department of Pediatric Endocrinology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Pediatr Dermatol. 2008 Sep-Oct;25(5):544-7. doi: 10.1111/j.1525-1470.2008.00735.x.
Topical use of corticosteroids may cause immunosuppression and iatrogenic Cushing's syndrome via hypothalamic-pituitary-adrenal axis. We report two cases with iatrogenic Cushing's syndrome with different clinical outcomes due to abuse of same potent topical steroid clobetasol propionate. One of them died because of fatal disseminated cytomegalovirus infection. The other patient recovered completely. Physicians and parents should be informed about the adverse effects of such potent topical corticosteroids and physicians should prescribe less potent agents, especially during infancy.
局部使用皮质类固醇可能通过下丘脑-垂体-肾上腺轴导致免疫抑制和医源性库欣综合征。我们报告了两例因滥用同一种强效局部类固醇丙酸氯倍他索而导致医源性库欣综合征的病例，其临床结局不同。其中一例因致命的播散性巨细胞病毒感染死亡。另一例患者完全康复。应告知医生和家长此类强效局部皮质类固醇的不良反应，医生应开具效力较低的药物，尤其是在婴儿期。
