1 Headache Science Center, C. Mondino Foundation, Pavia, Italy.
2 Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Cephalalgia. 2018 Apr;38(5):815-832. doi: 10.1177/0333102418758283. Epub 2018 Mar 4.
Background Quality clinical trials form an essential part of the evidence base for the treatment of headache disorders. In 1991, the International Headache Society Clinical Trials Standing Committee developed and published the first edition of the Guidelines for Controlled Trials of Drugs in Migraine. In 2008, the Committee published the first specific guidelines on chronic migraine. Subsequent advances in drug, device, and biologicals development, as well as novel trial designs, have created a need for a revision of the chronic migraine guidelines. Objective The present update is intended to optimize the design of controlled trials of preventive treatment of chronic migraine in adults, and its recommendations do not apply to trials in children or adolescents.
背景 高质量的临床试验是头痛疾病治疗证据基础的重要组成部分。1991 年，国际头痛协会临床试验常务委员会制定并发布了偏头痛药物对照试验指南的第一版。2008 年，委员会发布了慢性偏头痛的第一个专门指南。随后药物、设备和生物制品的开发以及新的试验设计方面的进展，使得修订慢性偏头痛指南成为必要。 目的 本次更新旨在优化成人慢性偏头痛预防性治疗的对照试验设计，其建议不适用于儿童或青少年的试验。
