Polácek H, Korpás J, Tatár M, Plank L, Pullmann R
Physiol Bohemoslov. 1986;35(6):481-9.
The authors studied parameters of laryngopharyngeal (LPh) and tracheobronchial (TB) cough (the number of efforts--NE, the number of efforts per minute--NE.min-1, the intensity of the maximum effort--IME and the intensity of the attack--IA), respiratory parameters (VT, f, Cdyn), blood gas values (PaO2, PaCO2) and the pH in the arterial blood of anaesthetized cats (Pentobarbital Spofa, 35 mg x kg-1 i.p. with experimental pulmonary oedema. Oedema was induced by the i.v. administration of a fatty acid mixture (capric acid 3.8 g, caprylic acid 3.1 g and olive oil 3.0 g)--in a dose of 0.05 ml x kg-1 in group 1 and of 0.01 ml x kg-1 in group 2. Cough was elicited by stimulating the laryngopharyngeal and tracheobronchial mucosa with a silon fibre. Pulmonary oedema was determined from a macroscopic and microscopic examination of the lungs, from the ratio of lung weight to body weight and from the percentual dry weight of the right lungs. The authors found that the intensity of cough was depressed during pulmonary oedema, particularly in the case of TB cough. VT and Cdyn fell, f rose and the PaO2 and pH values steadily decreased.
作者研究了喉咽（LPh）和气管支气管（TB）咳嗽的参数（咳嗽次数-NE、每分钟咳嗽次数-NE.min-1、最大咳嗽强度-IME和咳嗽发作强度-IA）、呼吸参数（潮气量-VT、呼吸频率-f、动态顺应性-Cdyn）、血气值（动脉血氧分压-PaO2、动脉血二氧化碳分压-PaCO2）以及麻醉猫（戊巴比妥钠，35mg/kg腹腔注射，伴有实验性肺水肿）动脉血中的pH值。肺水肿通过静脉注射脂肪酸混合物（癸酸3.8g、辛酸3.1g和橄榄油3.0g）诱导产生，第1组剂量为0.05ml/kg，第2组剂量为0.01ml/kg。用硅酮纤维刺激喉咽和气管支气管黏膜引发咳嗽。通过对肺进行宏观和微观检查、肺重量与体重之比以及右肺的干重百分比来确定肺水肿情况。作者发现，肺水肿期间咳嗽强度降低，尤其是TB咳嗽。VT和Cdyn下降，f升高，PaO2和pH值持续下降。
