Korpás J, Widdicombe J G, Vrabec M, Kudlicka J
Department of Pathophysiology, Faculty of Medicine, Comenius University, Martin, Czechoslovakia.
Respir Med. 1993 Jan;87(1):55-9. doi: 10.1016/s0954-6111(05)80314-2.
We have assessed the importance of changes in lung structure on the pattern of cough sound and its creation with 13 anaesthetized cats. Acute lung injury with oedema was induced by i.v. administration of a mixture of fatty acids. Cough was elicited by mechanical stimulation of the mucous membranes of the airways and was evaluated by its intensities of effort and sound before and up to 2 h after administration of the fatty acids. Changes of cough sound pattern were not definitive, there being no typical alterations. The cough effort and sound intensities, induced from the trachea, consistently decreased (by 70-80% in both cases). The cough efforts immediately after induction of oedema were transiently abolished in some cats. The cough values induced from the larynx similarly decreased at 5 min (51-57%) but subsequently gradually returned to control values. There were significant correlations, both for coughs induced from the trachea and from the larynx, and for changes in intensity of efforts compared with sounds. Thus, pathological changes in the lungs modify the intensities both of cough efforts and their associated sounds.
我们用13只麻醉猫评估了肺结构变化对咳嗽声音模式及其产生的重要性。通过静脉注射脂肪酸混合物诱导急性肺水肿性肺损伤。通过机械刺激气道黏膜引发咳嗽，并在注射脂肪酸之前及之后长达2小时内，根据咳嗽的用力强度和声音强度对咳嗽进行评估。咳嗽声音模式的变化并不明确，没有典型的改变。从气管引发的咳嗽用力和声音强度持续下降（两种情况均下降70 - 80%）。在一些猫中，水肿诱导后立即出现的咳嗽用力会短暂消失。从喉部引发的咳嗽值在5分钟时同样下降（51 - 57%），但随后逐渐恢复到对照值。对于从气管和喉部引发的咳嗽，以及与声音相比用力强度的变化，都存在显著相关性。因此，肺部的病理变化会改变咳嗽用力及其相关声音的强度。
