一步法制备多糖聚合物的抗菌和抗氧化性能增强：接枝到壳聚糖上的曲酸。
One-step procedure for enhancing the antibacterial and antioxidant properties of a polysaccharide polymer: Kojic acid grafted onto chitosan.
机构信息
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Lihu Road 1800, Wuxi 214122, Jiangsu, People's Republic of China.
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Lihu Road 1800, Wuxi 214122, Jiangsu, People's Republic of China.
出版信息
Int J Biol Macromol. 2018 Jul 1;113:1125-1133. doi: 10.1016/j.ijbiomac.2018.03.007. Epub 2018 Mar 2.
The purpose of this work was to develop a nontoxic bioactive material based on a natural pyrone compound (kojic acid, KA) and chitosan oligosaccharides (COS). The bioactive material, chitosan oligosaccharide-N-kojic acid polymer (COS-N-KA), was prepared by one-step environmentally friendly approach. Then, the physicochemical properties and biological activities of COS-N-KA as a prepared water-soluble COS derivative were evaluated. The polymer was characterized by using UV-vis, FTIR, H NMR, and C NMR spectroscopy, Mw, PID, TGA, water solubility, hemolysis assay, and animal toxicity studies. Particularly, the antioxidant and antimicrobial assays revealed that COS-N-KA significantly enhanced the antimicrobial and antioxidant activities, which remarkably stronger than that of free COS and KA. Hence, the low hemolytic activity to human red blood cells, and nontoxic to female mice of SLAC KM strain made this novel polymer material a promising and effective compound for food and pharmaceutical industries.
这项工作的目的是开发一种基于天然吡喃酮化合物（曲酸，KA）和壳寡糖（COS）的无毒生物活性材料。生物活性材料壳寡糖-N-曲酸聚合物（COS-N-KA）通过一步环保方法制备。然后，评估了作为水溶性 COS 衍生物的 COS-N-KA 的物理化学性质和生物活性。通过使用 UV-vis、FTIR、H NMR 和 C NMR 光谱、Mw、PID、TGA、水溶性、溶血试验和动物毒性研究对聚合物进行了表征。特别是，抗氧化和抗菌测定表明，COS-N-KA 显著增强了抗菌和抗氧化活性，比游离 COS 和 KA 强得多。因此，对人红细胞的低溶血活性以及对 SLAC KM 品系雌性小鼠的无毒作用，使这种新型聚合物材料成为食品和制药行业有前途和有效的化合物。
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