肌酸激酶（CK）及其与精神分裂症患者攻击行为的关系。
Creatine kinase (CK) and its association with aggressive behavior in patients with schizophrenia.
机构信息
The Mental Health Center of West China Hospital, Sichuan University, Chengdu City, Sichuan Province 610041, China.
College of Nursing, Chengdu Medical College, Chengdu City, Sichuan Province 610041, China.
出版信息
Schizophr Res. 2018 Jul;197:478-483. doi: 10.1016/j.schres.2018.02.025. Epub 2018 Mar 3.
OBJECTIVE
To study the association between the serum creatine kinase (CK) level and aggressive behavior in patients with schizophrenia.
METHOD
This retrospective study recruited 2780 Chinese patients with schizophrenia from January 2009 to December 2013 at the psychiatric inpatient units of West China Hospital. The diagnosis was made according to the DSM-IV criteria. The serum level of CK was checked.
RESULTS
Aggressive behavior was positively correlated with the serum CK level (r=0.262, p=0.000). The OR value is 8.084 when comparing the high CK group and normal CK group prior to admission. The aggressive behavior rate in the 5 times group (serum level≥1130U/L) after admission (28.2%) is higher than the rate prior to admission (16.5%).
CONCLUSION
The aggressive patients with schizophrenia displayed increased serum CK level. It may be useful to include a lab test of CK level in patients with schizophrenia and history of aggression. It would help the staff to take precautions to protect the patients and others.
目的
研究精神分裂症患者血清肌酸激酶（CK）水平与攻击行为之间的关系。
方法
本回顾性研究于 2009 年 1 月至 2013 年 12 月在华西医院精神科住院部招募了 2780 例中国精神分裂症患者。根据 DSM-IV 标准进行诊断。检查血清 CK 水平。
结果
攻击行为与血清 CK 水平呈正相关（r=0.262，p=0.000）。入院前比较高 CK 组和正常 CK 组时，OR 值为 8.084。入院后（血清水平≥1130U/L） 5 倍组（28.2%）的攻击行为发生率高于入院前（16.5%）。
结论
具有攻击性行为的精神分裂症患者血清 CK 水平升高。在有攻击行为史的精神分裂症患者中包括 CK 水平的实验室检查可能是有用的。这有助于工作人员采取预防措施保护患者和他人。
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