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肝硬化继发门静脉高压患者的妊娠情况。

Pregnancy in a patient with portal hypertension secondary to liver cirrhosis.

作者信息

Lelei-Mailu Faith Jelagat, Mariara Charles Muriuki

机构信息

Department of Family Medicine, AIC Kijabe Hospital, Kijabe, Kenya.

Department of Obstetrics and Gynaecology, AIC Kijabe Hospital, Kenya.

出版信息

BMJ Case Rep. 2018 Mar 5;2018:bcr-2017-223076. doi: 10.1136/bcr-2017-223076.

DOI:10.1136/bcr-2017-223076
PMID:29507022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5847992/
Abstract

This case report is of a 32-year-old woman of African descent on follow-up for pregnancy in the background of portal hypertension due to liver cirrhosis. She had initially been treated for chronic hepatitis B infection with lamivudine and tenofovir, complicated by portal hypertension and variceal bleeding that thrice required banding. Her pregnancy was uneventful until 31 weeks gestation when she presented with dyspnoea. On examination and investigation, she had oedema, bilateral pleural effusions and ascites. Multidisciplinary discussions involving surgery, anaesthesia, obstetrics, neonatology and medicine were held. A consensus outpatient and inpatient management plan was implemented. At 36 weeks, following non-reassuring fetal cardiotocography, she underwent induction of labour. An assisted vacuum delivery was conducted in a controlled setting. She gave birth to a live female infant who had an APGAR score of 9 at 5 min. Both she and the baby had an uneventful postpartum period.

摘要

本病例报告的是一名32岁的非洲裔女性,因肝硬化导致门静脉高压而在孕期接受随访。她最初因慢性乙型肝炎感染接受拉米夫定和替诺福韦治疗,并发门静脉高压和静脉曲张出血,曾三次接受套扎治疗。她的孕期一直顺利,直到妊娠31周时出现呼吸困难。经检查和调查,她有水肿、双侧胸腔积液和腹水。组织了包括外科、麻醉科、产科、新生儿科和内科的多学科讨论。实施了门诊和住院的共识管理计划。36周时,因胎儿心动图检查结果不理想,她接受了引产。在可控环境下进行了真空辅助分娩。她生下了一名活女婴,5分钟时阿氏评分9分。她和婴儿产后情况均良好。

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本文引用的文献

1
The pathophysiology of thrombocytopenia in chronic liver disease.慢性肝病中血小板减少症的病理生理学
Hepat Med. 2016 Apr 15;8:39-50. doi: 10.2147/HMER.S74612. eCollection 2016.
2
ACG Clinical Guideline: Liver Disease and Pregnancy.美国胃肠病学会临床指南:肝病与妊娠
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Pregnancy and liver disease.妊娠与肝脏疾病。
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4
Hepatitis B surface antigen quantification as a predictor of seroclearance during treatment in HIV-hepatitis B virus coinfected patients from Sub-Saharan Africa.乙型肝炎表面抗原定量作为撒哈拉以南非洲地区艾滋病毒-乙型肝炎病毒合并感染患者治疗期间血清学清除的预测指标。
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Pregnancy with portal hypertension.妊娠合并门静脉高压症。
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Gastrointestinal endoscopy in pregnancy.妊娠期胃肠内镜检查
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Risks versus benefits of gastrointestinal endoscopy during pregnancy.孕期行胃肠内镜检查的风险与获益。
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The outcomes of pregnancy in patients with cirrhosis: a population-based study.肝硬化患者妊娠结局的研究:一项基于人群的研究。
Liver Int. 2010 Feb;30(2):275-83. doi: 10.1111/j.1478-3231.2009.02153.x. Epub 2009 Oct 27.
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Pregnancy and cirrhosis.妊娠与肝硬化
Liver Transpl. 2008 Aug;14(8):1081-91. doi: 10.1002/lt.21572.