较高的视网膜血管氧饱和度：探究其与色素性视网膜炎患者黄斑水肿的关系。
Higher retinal vessel oxygen saturation: investigating its relationship with macular oedema in retinitis pigmentosa patients.
作者信息
Bojinova Rossiana I, Schorderet Daniel F, Valmaggia Christophe, Türksever Cengiz, Schoetzau Andreas, Todorova Margarita G
机构信息
Department of Ophthalmology, University of Basel, Mittlere Strasse 91, Basel, CH-4031, Switzerland.
University of Montreal, 495 Prince Arthur West, Montreal, H2X1T4, Canada.
出版信息
Eye (Lond). 2018 Jul;32(7):1209-1219. doi: 10.1038/s41433-018-0043-1. Epub 2018 Mar 6.
PURPOSE
Primary objective-to investigate the effect of retinal vessel oxygen saturation (SO) on macular oedema (ME) in retinitis pigmentosa (RP) patients. Secondary objective-to link the presence of ME to metabolic (oxygen saturation of retinal vessels, SO), functional (multifocal electroretinography, mfERG) and structural (Spectral Domain Optical Coherent Tomography, SD-OCT) alterations in RP.
DESIGN
Prospective, cross-sectional, non-interventional study.
SUBJECTS
Patients with typical RP (N = 37) and controls (N = 19), who underwent retinal vessel Oximetry (RO), SD-OCT and mfERG, were included.
METHODS
A computer-based program of the retinal vessel analyser unit (IMEDOS Systems UG, Jena, Germany) was used to measure SO. We evaluated the mean SO, in all major retinal arterioles (oxygen saturation in retinal arterioles, A-SO, %) and venules (oxygen saturation in retinal venules, V-SO, %). MfERG responses were averaged in zones (zone 1 (0-3°), zone 2 (3-8°) and zone 3 (8-15°)) and compared to corresponding areas of the OCT. The effect of ME on SO was evaluated dividing the RP in two subgroups: with clinical appearance of ME (ME-RP) and without it (no-ME-RP).
MAIN OUTCOME MEASURES
Parallel recording and juxtaposition of metabolic (SO) to structural (OCT) and functional-(mfERG) measures. Mean ( ± SD) A-SO and V-SO were higher in no-ME-RP (96.77% (±6.31) and 59.93% (±7.76)) and even higher in the ME-RP (99.82% (±6.21) and 65.63% (±7.63)), compared to controls (93.15% (±3.76) and 53.77% (±3.70), p ≤ 0.006).
RESULTS
The subgroup ME-RP differed significantly from the subgroup no-ME-RP by increased A-SO and V-SO, p ≤ 0.026. The presence of ME confirmed a different relationship between the altered SO and the vessel diameters, against the functional and structural parameters.
CONCLUSION
Based on our results, the presence of macular oedema indicates a tendency toward greater alteration of the metabolic function in RP patients.
目的
主要目标——研究视网膜色素变性（RP）患者视网膜血管血氧饱和度（SO）对黄斑水肿（ME）的影响。次要目标——将ME的存在与RP患者的代谢（视网膜血管血氧饱和度，SO）、功能（多焦视网膜电图，mfERG）和结构（光谱域光学相干断层扫描，SD-OCT）改变联系起来。
设计
前瞻性、横断面、非干预性研究。
研究对象
纳入了接受视网膜血管血氧测定（RO）、SD-OCT和mfERG检查的典型RP患者（N = 37）和对照组（N = 19）。
方法
使用基于计算机的视网膜血管分析仪单元程序（德国耶拿的IMEDOS Systems UG）测量SO。我们评估了所有主要视网膜小动脉（视网膜小动脉血氧饱和度，A-SO，%）和小静脉（视网膜小静脉血氧饱和度，V-SO，%）的平均SO。mfERG反应在不同区域（区域1（0 - 3°）、区域2（3 - 8°）和区域3（8 - 15°））进行平均，并与OCT的相应区域进行比较。通过将RP患者分为两个亚组来评估ME对SO的影响：有ME临床表现的（ME-RP）和没有ME临床表现的（无ME-RP）。
主要观察指标
代谢（SO）与结构（OCT）和功能（mfERG）测量的并行记录和并列比较。与对照组（93.15%（±3.76）和53.77%（±3.70），p≤0.006）相比，无ME-RP组的平均（±标准差）A-SO和V-SO更高（分别为96.77%（±6.31）和59.93%（±7.76）），ME-RP组甚至更高（分别为99.82%（±6.21）和65.63%（±7.63））。
结果
ME-RP亚组与无ME-RP亚组相比，A-SO和V-SO升高，差异有统计学意义，p≤0.026。ME的存在证实了SO改变与血管直径之间存在不同于功能和结构参数的关系。
结论
基于我们的研究结果，黄斑水肿的存在表明RP患者代谢功能有更大改变的倾向。
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