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中枢神经系统内皮细胞活化的分子磁共振成像。

Molecular Magnetic Resonance Imaging of Endothelial Activation in the Central Nervous System.

机构信息

Normandie Univ, UNICAEN, INSERM, INSERM UMR-S U1237, Physiopathology and Imaging for Neurological Disorders (PhIND), Cyceron, 14000 Caen, France.

CHU Caen, Department of diagnostic imaging and interventional radiology, CHU de Caen Côte de Nacre, Caen, France.

出版信息

Theranostics. 2018 Feb 2;8(5):1195-1212. doi: 10.7150/thno.22662. eCollection 2018.

DOI:10.7150/thno.22662
PMID:29507614
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5835930/
Abstract

Endothelial cells of the central nervous system over-express surface proteins during neurological disorders, either as a cause, or a consequence, of the disease. Since the cerebral vasculature is easily accessible by large contrast-carrying particles, it constitutes a target of choice for molecular magnetic resonance imaging (MRI). In this review, we highlight the most recent advances in molecular MRI of brain endothelial activation and focus on the development of micro-sized particles of iron oxide (MPIO) targeting adhesion molecules including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), P-Selectin and E-Selectin. We also discuss the perspectives and challenges for the clinical application of this technology in neurovascular disorders (ischemic stroke, intracranial hemorrhage, subarachnoid hemorrhage, diabetes mellitus), neuroinflammatory disorders (multiple sclerosis, brain infectious diseases, sepsis), neurodegenerative disorders (Alzheimer's disease, vascular dementia, aging) and brain cancers (primitive neoplasms, metastasis).

摘要

中枢神经系统的内皮细胞在神经疾病期间过度表达表面蛋白，无论是作为疾病的原因还是结果。由于脑脉管系统很容易被大的载造影剂颗粒接近，因此它成为分子磁共振成像（MRI）的首选目标。在这篇综述中，我们强调了脑内皮细胞激活的分子 MRI 的最新进展，并重点介绍了针对细胞间黏附分子 1（ICAM-1）、血管细胞黏附分子 1（VCAM-1）、P-选择素和 E-选择素等黏附分子的超顺磁性氧化铁（MPIO）微颗粒的开发。我们还讨论了该技术在神经血管疾病（缺血性中风、颅内出血、蛛网膜下腔出血、糖尿病）、神经炎症性疾病（多发性硬化症、脑传染性疾病、脓毒症）、神经退行性疾病（阿尔茨海默病、血管性痴呆、衰老）和脑癌（原始肿瘤、转移）中的临床应用的前景和挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/5835930/eb030012f4a0/thnov08p1195g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/5835930/4c7d6422b935/thnov08p1195g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/5835930/dabe571e9dc4/thnov08p1195g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/5835930/745ef4dba70b/thnov08p1195g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/5835930/9dcb06977fde/thnov08p1195g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/5835930/1d4bed7dd1e6/thnov08p1195g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/5835930/123fbdc6aec3/thnov08p1195g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/5835930/eb030012f4a0/thnov08p1195g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/5835930/4c7d6422b935/thnov08p1195g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/5835930/dabe571e9dc4/thnov08p1195g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/5835930/745ef4dba70b/thnov08p1195g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/5835930/9dcb06977fde/thnov08p1195g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/5835930/1d4bed7dd1e6/thnov08p1195g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/5835930/123fbdc6aec3/thnov08p1195g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b421/5835930/eb030012f4a0/thnov08p1195g007.jpg

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