Jiménez Adriana, Estudillo Enrique, Guzmán-Ruiz Mara A, Herrera-Mundo Nieves, Victoria-Acosta Georgina, Cortés-Malagón Enoc Mariano, López-Ornelas Adolfo
División de Investigación, Hospital Juárez de México, Ciudad de México 07760, Mexico.
Laboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México 14269, Mexico.
Pharmaceutics. 2025 Feb 20;17(3):281. doi: 10.3390/pharmaceutics17030281.
The blood-brain barrier (BBB) is a critical structure that maintains brain homeostasis by selectively regulating nutrient influx and waste efflux. Not surprisingly, it is often compromised in neurodegenerative diseases. In addition to its involvement in these pathologies, the BBB also represents a significant challenge for drug delivery into the central nervous system. Nanoparticles (NPs) have been widely explored as drug carriers capable of overcoming this barrier and effectively transporting therapies to the brain. However, their potential to directly address and ameliorate BBB dysfunction has received limited attention. In this review, we examine how NPs enhance drug delivery across the BBB to treat neurodegenerative diseases and explore emerging strategies to restore the integrity of this vital structure.
血脑屏障（BBB）是一种关键结构，通过选择性调节营养物质的流入和废物的流出维持脑内稳态。不出所料，它在神经退行性疾病中常常受到损害。除了参与这些病理过程外，血脑屏障对于药物输送到中枢神经系统来说也是一个重大挑战。纳米颗粒（NPs）作为能够克服这一屏障并有效将治疗药物输送到大脑的药物载体已得到广泛研究。然而，它们直接解决和改善血脑屏障功能障碍的潜力却受到了有限的关注。在这篇综述中，我们研究了纳米颗粒如何增强跨血脑屏障的药物递送以治疗神经退行性疾病，并探索恢复这一重要结构完整性的新策略。
