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纳米技术克服神经退行性疾病中的血脑屏障通透性及损伤

Nanotechnology to Overcome Blood-Brain Barrier Permeability and Damage in Neurodegenerative Diseases.

作者信息

Jiménez Adriana, Estudillo Enrique, Guzmán-Ruiz Mara A, Herrera-Mundo Nieves, Victoria-Acosta Georgina, Cortés-Malagón Enoc Mariano, López-Ornelas Adolfo

机构信息

División de Investigación, Hospital Juárez de México, Ciudad de México 07760, Mexico.

Laboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México 14269, Mexico.

出版信息

Pharmaceutics. 2025 Feb 20;17(3):281. doi: 10.3390/pharmaceutics17030281.

DOI:10.3390/pharmaceutics17030281
PMID:40142945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11945272/
Abstract

The blood-brain barrier (BBB) is a critical structure that maintains brain homeostasis by selectively regulating nutrient influx and waste efflux. Not surprisingly, it is often compromised in neurodegenerative diseases. In addition to its involvement in these pathologies, the BBB also represents a significant challenge for drug delivery into the central nervous system. Nanoparticles (NPs) have been widely explored as drug carriers capable of overcoming this barrier and effectively transporting therapies to the brain. However, their potential to directly address and ameliorate BBB dysfunction has received limited attention. In this review, we examine how NPs enhance drug delivery across the BBB to treat neurodegenerative diseases and explore emerging strategies to restore the integrity of this vital structure.

摘要

血脑屏障（BBB）是一种关键结构，通过选择性调节营养物质的流入和废物的流出维持脑内稳态。不出所料，它在神经退行性疾病中常常受到损害。除了参与这些病理过程外，血脑屏障对于药物输送到中枢神经系统来说也是一个重大挑战。纳米颗粒（NPs）作为能够克服这一屏障并有效将治疗药物输送到大脑的药物载体已得到广泛研究。然而，它们直接解决和改善血脑屏障功能障碍的潜力却受到了有限的关注。在这篇综述中，我们研究了纳米颗粒如何增强跨血脑屏障的药物递送以治疗神经退行性疾病，并探索恢复这一重要结构完整性的新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6c/11945272/8a3dd96cad05/pharmaceutics-17-00281-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6c/11945272/02f96a8aefc3/pharmaceutics-17-00281-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6c/11945272/943eca8654ed/pharmaceutics-17-00281-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6c/11945272/4b34d59edb07/pharmaceutics-17-00281-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6c/11945272/9c1d419ba6b3/pharmaceutics-17-00281-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6c/11945272/090d4bba42da/pharmaceutics-17-00281-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6c/11945272/8a3dd96cad05/pharmaceutics-17-00281-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6c/11945272/02f96a8aefc3/pharmaceutics-17-00281-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6c/11945272/943eca8654ed/pharmaceutics-17-00281-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6c/11945272/4b34d59edb07/pharmaceutics-17-00281-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6c/11945272/9c1d419ba6b3/pharmaceutics-17-00281-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6c/11945272/090d4bba42da/pharmaceutics-17-00281-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6c/11945272/8a3dd96cad05/pharmaceutics-17-00281-g006.jpg

相似文献

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Nanotechnology to Overcome Blood-Brain Barrier Permeability and Damage in Neurodegenerative Diseases.

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[2]
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[4]
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[5]
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[10]
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[2]
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[3]
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[4]
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本文引用的文献

[1]
Nanoparticle Strategies for Treating CNS Disorders: A Comprehensive Review of Drug Delivery and Theranostic Applications.

Int J Mol Sci. 2024-12-11

[2]
Advances in genetically modified neural stem cell therapy for central nervous system injury and neurological diseases.

Stem Cell Res Ther. 2024-12-18

[3]
A pH-sensitive liposomal co-delivery of fingolimod and ammonia borane for treatment of intracerebral hemorrhage.

Nanophotonics. 2022-11-2

[4]
Targeting Glucose Metabolism: A Novel Therapeutic Approach for Parkinson's Disease.

Cells. 2024-11-13

[5]
Mesenchymal stromal cell therapies for traumatic neurological injuries.

J Transl Med. 2024-11-22

[6]
Curcumin-Loaded Gelatin Nanoparticles Cross the Blood-Brain Barrier to Treat Ischemic Stroke by Attenuating Oxidative Stress and Neuroinflammation.

Int J Nanomedicine. 2024

[7]
Exploring mesenchymal stem cells homing mechanisms and improvement strategies.

Stem Cells Transl Med. 2024-12-16

[8]
Amyotrophic Lateral Sclerosis: Insights and New Prospects in Disease Pathophysiology, Biomarkers and Therapies.

Pharmaceuticals (Basel). 2024-10-18

[9]
The evolution of mesenchymal stem cell-derived neural progenitor therapy for Multiple Sclerosis: from concept to clinic.

Front Cell Neurosci. 2024-8-29

[10]
A review of metallic nanoparticles: present issues and prospects focused on the preparation methods, characterization techniques, and their theranostic applications.

Front Chem. 2024-8-14

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