Thirkill C E, Roth A M, Keltner J L
Arch Ophthalmol. 1987 Mar;105(3):372-5. doi: 10.1001/archopht.1987.01060030092033.
Antiretina antibodies have been found in the serum samples of four patients with cancer experiencing concomitant loss of vision (cancer-associated retinopathy [CAR] syndrome). These immunoglobulins bound an antigen from normal pooled retina having a molecular weight of 23,000 daltons, which we describe as the CAR antigen. No corresponding antibodies could be found in serum samples obtained from patients with cancer not experiencing vision loss, from patients having retinitis pigmentosa, or from normally sighted individuals who did not have cancer. The early detection of rising antibody titers against the CAR antigen could prove important in the identification of patients likely to suffer from CARs.
在四名伴有视力丧失的癌症患者（癌症相关性视网膜病变[CAR]综合征）的血清样本中发现了抗视网膜抗体。这些免疫球蛋白与来自正常混合视网膜的一种分子量为23,000道尔顿的抗原结合，我们将其描述为CAR抗原。在未出现视力丧失的癌症患者、患有色素性视网膜炎的患者或无癌症的视力正常个体的血清样本中未发现相应抗体。早期检测针对CAR抗原的抗体滴度升高可能对识别可能患有CARs的患者很重要。
