铁催化的芳基-2H-氮丙啶与高价碘(III)试剂的 C(sp)-H 酰氧基化反应。
Iron-Catalyzed C(sp)-H Acyloxylation of Aryl-2 H Azirines with Hypervalent Iodine(III) Reagents.
机构信息
Department of Chemistry , Huaibei Normal University , Huaibei , Anhui 235000 , P. R. China.
State Key Laboratory of Organometallic Chemistry , Shanghai Institute of Organic Chemistry , Shanghai 200032 , P. R. China.
出版信息
Org Lett. 2018 Mar 16;20(6):1663-1666. doi: 10.1021/acs.orglett.8b00442. Epub 2018 Mar 6.
PMID:29508617
Abstract
This letter describes an iron-catalyzed C(sp)-H acyloxylation of aryl-2 H azirines with hypervalent iodine(III) reagents (HIRs) serving as both an oxidant and a reagent. This methodology provides a rapid access to a wide range of monoacyloxylated 3-aryl-2 H-azirines in moderate to good yields.
摘要
这封信描述了一种铁催化的芳基-2H-氮丙啶与高价碘(III)试剂（HIR）的 C(sp)-H 酰氧基化反应，其中 HIR 既作为氧化剂又作为试剂。该方法为合成多种单酰氧基化的 3-芳基-2H-氮丙啶提供了一条快速通道，产率中等至良好。
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