School of Chemistry and Chemical Engineering , South China University of Technology , Guangzhou 510640 , People's Republic of China.
J Org Chem. 2018 Apr 6;83(7):3710-3718. doi: 10.1021/acs.joc.8b00066. Epub 2018 Mar 12.
An oxidative coupling reaction between purines and alkyl ethers/benzyl compounds was developed to synthesize a series of N9 alkylated purine derivatives using n-BuNI as a catalyst and t-BuOOH as an oxidant. This protocol uses commercially available, inexpensive catalysts and oxidants and has a wide range of substrates with a simple operation.
嘌呤和烷基醚/苄基化合物之间的氧化偶联反应被开发出来，使用 n-BuNI 作为催化剂和 t-BuOOH 作为氧化剂，合成了一系列 N9 烷基化嘌呤衍生物。该方案使用商业可得的、廉价的催化剂和氧化剂，具有广泛的底物范围，操作简单。
