Lu Changtong, Histand Gary, Lin Dongen
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
International School of Advanced Materials, South China University of Technology, Guangzhou 510641, China.
Org Biomol Chem. 2023 Apr 12;21(15):3167-3171. doi: 10.1039/d3ob00147d.
The one-step visible light-induced direct alkylation of the C-H bond for purine derivatives by ethers was developed using Eosin Y as the photocatalyst and -BuOOH as the oxidant at room temperature. This method describes the coupling of the α-C of the ether to the C of purine. Of particular interest is that substrates include purines with various functional groups and even unprotected 9-purines. The protocol provides an effective method for the synthesis of 8-alkylpurine derivatives with high atom economy and high regioselectivity.
以曙红Y为光催化剂，叔丁基过氧化氢为氧化剂，在室温下实现了醚对嘌呤衍生物C-H键的一步可见光诱导直接烷基化反应。该方法描述了醚的α-C与嘌呤的C的偶联。特别值得注意的是，底物包括具有各种官能团的嘌呤，甚至是未保护的9-嘌呤。该方案为合成具有高原子经济性和高区域选择性的8-烷基嘌呤衍生物提供了一种有效方法。
