Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
International School of Advanced Materials, South China University of Technology, Guangzhou 510640, China.
Org Biomol Chem. 2021 Jun 16;19(23):5121-5126. doi: 10.1039/d1ob00118c.
An efficient oxidative functionalization of purine-like substrates with (thio)ethers or methylarenes under mild conditions is described. Using I2 as the catalyst, and TBHP as the oxidant, this protocol provides a valuable synthetic tool for the assembly of a wide range of 9-alkyl(benzyl)purin-8-one derivatives with high atom- and step-economy and exceptional functional group tolerance.
本文描述了在温和条件下，通过（硫）醚或甲基芳烃对嘌呤样底物的高效氧化官能化反应。该方法以 I2 为催化剂，TBHP 为氧化剂，为合成各种 9-烷基（苄基）嘌呤-8-酮衍生物提供了一种有价值的合成工具，具有高原子经济性和步骤经济性以及出色的官能团耐受性。
