实性型甲状腺乳头状癌的预后意义：系统评价和荟萃分析。
Prognostic importance of solid variant papillary thyroid carcinoma: A systematic review and meta-analysis.
机构信息
Department of Pathology, University of Yamanashi, Yamanashi, Japan.
Department of Pathology, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
出版信息
Head Neck. 2018 Jul;40(7):1588-1597. doi: 10.1002/hed.25123. Epub 2018 Mar 6.
BACKGROUND
Solid variant papillary thyroid carcinoma (SVPTC) is a rare variant of papillary thyroid cancer (PTC) and its prognostic value is still unclear. The purpose of this systematic clinical review and meta-analysis is to investigate the prognostic value of SVPTC in comparison with classical PTC (cPTC).
METHODS
Four electronic databases, including PubMed, Scopus, Web of Science, and Virtual Health Library, were searched in June 2017. Extracted data were pooled into odds ratio (OR) or hazard ratio (HR) and their corresponding 95% confidence interval (CI) using the random-effect model.
RESULTS
From 1439 articles, we finally included 11 studies with 205 SVPTCs for meta-analysis. Overall, SVPTC manifested a significantly higher risk for vascular invasion, tumor recurrence, and cancer mortality as compared to cPTC. The genetic profile of SVPTC was also distinct from that of cPTC.
CONCLUSION
A case of SVPTC should be regarded as an aggressive variant of PTC because of a higher risk for tumor recurrence and mortality.
背景
实性细胞为主型甲状腺乳头状癌（SVPTC）是甲状腺乳头状癌（PTC）的罕见变体，其预后价值尚不清楚。本系统临床综述和荟萃分析的目的是调查 SVPTC 与经典 PTC（cPTC）相比的预后价值。
方法
2017 年 6 月，我们在四个电子数据库（PubMed、Scopus、Web of Science 和 Virtual Health Library）中进行了搜索。使用随机效应模型，将提取的数据汇总为优势比（OR）或风险比（HR）及其相应的 95%置信区间（CI）。
结果
从 1439 篇文章中，我们最终纳入了 11 项研究，共 205 例 SVPTC 进行荟萃分析。总体而言，与 cPTC 相比，SVPTC 表现出更高的血管侵犯、肿瘤复发和癌症死亡率风险。SVPTC 的遗传特征也与 cPTC 不同。
结论
由于肿瘤复发和死亡率的风险较高，SVPTC 应被视为 PTC 的侵袭性变体。
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