Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
Korea Institute of Vitiligo Research, Seoul, Korea.
Pigment Cell Melanoma Res. 2018 Sep;31(5):585-591. doi: 10.1111/pcmr.12699. Epub 2018 Mar 23.
Vitiligo has a substantial negative impact on quality of life in affected patients, especially those with the involvement of the face. However, the current system can barely distinguish between specific patterns of facial involvement except for the segmental type when focusing only on facial lesions. We classified facial vitiligo into three distinct subtypes using cluster analysis based on facial topography (n = 473): centrofacial vitiligo (72.9%), panfacial vitiligo (18.0%), and hairline vitiligo (9.1%). Centrofacial vitiligo was the most common type and is thought to comprise the typical facial involvement of generalized vitiligo. Panfacial vitiligo was a distinct subtype with onset in old age and less involvement of other body parts. Hairline vitiligo was another distinct subtype with onset in old age and a poor response to conventional phototherapy. A relevant classification system could help us to explore the causes, anticipate the prognosis, and manage the condition in patients with vitiligo.
白癜风对患者的生活质量有重大负面影响，尤其是面部受累的患者。然而，当前的系统在仅关注面部病变时，除节段型外，几乎无法区分特定的面部受累模式。我们基于面部拓扑结构（n=473）使用聚类分析将面部白癜风分为三种不同的亚型：中心型白癜风（72.9%）、全颜面型白癜风（18.0%）和发际线型白癜风（9.1%）。中心型白癜风是最常见的类型，被认为包括泛发性白癜风的典型面部受累。全颜面型白癜风是一种独特的亚型，发病年龄较大，其他身体部位受累较少。发际线型白癜风是另一种独特的亚型，发病年龄较大，对常规光疗反应不佳。相关的分类系统可以帮助我们探讨白癜风患者的病因、预测预后并进行病情管理。
