Tachibana T, Yoshida K
Cancer Metastasis Rev. 1986;5(2):55-66. doi: 10.1007/BF00046422.
At an early phase of tumor growth, T-cell responses, i.e. the proliferation of T cells and the generation of cytotoxic T cells or killer-augmenting T cells are induced in the regional lymph node depending upon the immunological properties of the tumor cells. A small number of tumor cells seems to be rejected in the regional lymph node in situ. A progressive tumor induces suppressor activity in the regional node. Suppressor cells facilitate tumor growth and lead to lymphatic metastasis. Thus, the regional lymph node operates only as a temporary barrier to tumor growth. Experimental studies have demonstrated that eradication of the suppressor cells and effective immunization, or both, lead to tumor rejection by augmenting the immunological activity of the regional lymph node.
在肿瘤生长的早期阶段,根据肿瘤细胞的免疫特性,会在区域淋巴结中诱导T细胞反应,即T细胞增殖以及细胞毒性T细胞或杀伤增强T细胞的产生。少量肿瘤细胞似乎会在区域淋巴结原位被排斥。进展性肿瘤会在区域淋巴结中诱导抑制活性。抑制细胞促进肿瘤生长并导致淋巴转移。因此,区域淋巴结仅作为肿瘤生长的临时屏障。实验研究表明,根除抑制细胞和进行有效免疫,或两者兼而有之,可通过增强区域淋巴结的免疫活性导致肿瘤被排斥。