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使用弥散张量成像评估语前聋儿童的脑白质。

Evaluation of Cerebral White Matter in Prelingually Deaf Children Using Diffusion Tensor Imaging.

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Cheonan, Republic of Korea.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

出版信息

Biomed Res Int. 2018 Feb 4;2018:6795397. doi: 10.1155/2018/6795397. eCollection 2018.

Abstract

This study compared white matter development in prelingually deaf and normal-hearing children using a tract-based spatial statistics (TBSS) method. Diffusion tensor imaging (DTI) was performed in 21 prelingually deaf (DEAF group) and 20 normal-hearing (HEAR group) subjects aged from 1.7 to 7.7 years. Using TBSS, we evaluated the regions of significant difference in fractional anisotropy (FA) between the groups. Correlations between FA values and age in each group were also analyzed using voxel-wise correlation analyses on the TBSS skeleton. Lower FA values of the white matter tract of Heschl's gyrus, the inferior frontooccipital fasciculus, the uncinate fasciculus, the superior longitudinal fasciculus, and the forceps major were evident in the DEAF group compared with those in the HEAR group below 4 years of age, while the difference was not significant in older subjects. We also found that age-related development of the white matter tracts may continue until 8 years of age in deaf children. These results imply that development of the cerebral white matter tracts is delayed in prelingually deaf children.

摘要

本研究采用基于体素的空间统计学(TBSS)方法比较了先天性耳聋和正常听力儿童的白质发育情况。对 21 名先天性耳聋(耳聋组)和 20 名正常听力(听力组)儿童进行了弥散张量成像(DTI)检查,年龄在 1.7 至 7.7 岁之间。使用 TBSS,我们评估了两组间各向异性分数(FA)差异有统计学意义的区域。还通过 TBSS 骨架上的体素相关性分析,对每个组中 FA 值与年龄之间的相关性进行了分析。与听力组相比,耳聋组在 4 岁以下时,其 Heschl 回白质束、下额枕束、钩束、上纵束和内囊前肢的 FA 值较低,而在年龄较大的儿童中,差异不显著。我们还发现,耳聋儿童的白质束与年龄相关的发育可能会持续到 8 岁。这些结果表明,先天性耳聋儿童的大脑白质束发育延迟。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/5817214/b4cbbfe1214f/BMRI2018-6795397.001.jpg

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