Islam Muhammad Torequl, Tabrez Shams, Jabir Nasimudeen R, Ali Murtaza, Kamal Mohammad Amjad, da Silva Araujo Lidiane, De Oliveira Santos Jose Victor, Da Mata Ana Maria Oliveira Ferreira, De Aguiar Rai Pablo Sousa, de Carvalho Melo Cavalcante Ana Amelia
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Curr Drug Metab. 2018;19(6):544-556. doi: 10.2174/1389200219666180302154551.
The popular drink, coffee (Coffea arabica) is under the great attention of late because of its promising pharmacological potential. Caffeine (the major constituent of coffee) is known for its prominent psychoactive impact. This review aims at highlighting the therapeutic potentials of caffeine and other five coffee components viz. caffeic acid, chlorogenic acids, cafestol, ferulic acid and kahweol and their mechanisms of action.
An up-to-date search was made with selected keywords in PubMed, Science Direct, Web of Science, Scopus, The American Chemical Society and miscellaneous databases (e.g., Google Scholar) for the published literature on the selected topic.
A number of pharmacological activities are attributed to these components that include anti-oxidant, antiinflammatory, immunomodulatory, anti-microbial, anti-cancer, cardioprotective and neuroprotective effects. In addition, osteogenesis (kahweol), anti-diabetic (caffeine, chlorogenic acid and ferulic acid) and hepatoprotective (chlorogenic acid) activities have also been reported by some of these components in the scientific literature. Caffeine has also been noted for adverse effect on the development of the brain at early stages and reproductive systems.
A more advanced pre-clinical and clinical trials are recommended to investigate the safety profiles of these coffee components before their use as possible therapeutics.
广受欢迎的饮品咖啡（阿拉伯咖啡）因其潜在的药理作用，近来备受关注。咖啡因（咖啡的主要成分）以其显著的精神活性影响而闻名。本综述旨在强调咖啡因以及其他五种咖啡成分，即咖啡酸、绿原酸、咖啡醇、阿魏酸和咖啡豆醇的治疗潜力及其作用机制。
在PubMed、科学Direct、科学网、Scopus、美国化学学会以及其他各类数据库（如谷歌学术）中，使用选定的关键词对所选主题的已发表文献进行了最新检索。
这些成分具有多种药理活性，包括抗氧化、抗炎、免疫调节、抗菌、抗癌、心脏保护和神经保护作用。此外，科学文献中还报道了其中一些成分具有成骨作用（咖啡豆醇）、抗糖尿病作用（咖啡因、绿原酸和阿魏酸）以及肝脏保护作用（绿原酸）。咖啡因还被指出对早期大脑发育和生殖系统有不良影响。
建议在将这些咖啡成分用作可能的治疗药物之前，进行更深入的临床前和临床试验，以研究其安全性。
