咖啡和茶的摄入量与骨质疏松症风险：一项荟萃分析。
Coffee and tea consumption on the risk of osteoporosis: a meta-analysis.
作者信息
Li Wopei, Xie Yujiao, Jiang Lei
机构信息
College of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Rehabilitation, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
出版信息
Front Nutr. 2025 Mar 4;12:1559835. doi: 10.3389/fnut.2025.1559835. eCollection 2025.
OBJECTIVES
This meta-analysis aims to quantify the relationship between coffee and tea consumption and the risk of osteoporosis and explore whether such consumption positively or negatively impacts this risk, thereby providing a scientific basis for understanding the effects of coffee and tea on bone health.
METHODS
We systematically searched PubMed, the Cochrane Library, and Embase for observational studies published up to November 5, 2024, using medical subject headings (MeSH) and keywords related to "osteoporosis, tea, and coffee." Statistical analyses were conducted using Stata software version 14.0. A fixed-effects model was used when heterogeneity was low ( ≤ 50% and > 0.1). A random-effects model was used for greater heterogeneity ( > 50%). Publication bias was assessed using funnel plots and Egger's regression tests.
RESULTS
This meta-analysis included 14 observational studies comprising 562,838 participants published between 2008 and 2024. The pooled analysis showed that coffee consumption is significantly associated with a reduced risk of osteoporosis (odds ratio [OR] = 0.79, 95% confidence interval [CI]: 0.73-0.84, = 28.9%, < 0.05). Tea consumption also demonstrated a protective effect, with a lower risk of osteoporosis (OR = 0.75, 95% CI: 0.62-0.91, = 80.4%, < 0.05). Subgroup analysis revealed that high-frequency coffee consumption (more than one cup per day) was associated with a greater reduction in osteoporosis risk (OR = 0.83, 95% CI: 0.74-0.93, = 0.001) compared to low-frequency consumption (less than one cup per day), which showed no statistically significant reduction (OR = 0.86, 95% CI: 0.68-1.07, = 0.171). Similarly, high-frequency tea consumption (more than four times per week) exhibited a slightly stronger protective effect against osteoporosis compared to low-frequency consumption (OR = 0.82, 95% CI: 0.70-0.97, = 0.02).
CONCLUSION
This meta-analysis suggests that long-term coffee and tea consumption is associated with a reduced risk of osteoporosis. Moreover, a higher frequency of consumption within a moderate range appeared to enhance the protective effect against osteoporosis.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024612101, PROSPERO CRD42024612101.
目的
本荟萃分析旨在量化咖啡和茶的摄入量与骨质疏松症风险之间的关系，并探讨这种摄入量对该风险产生的是积极还是消极影响，从而为理解咖啡和茶对骨骼健康的影响提供科学依据。
方法
我们使用医学主题词（MeSH）以及与“骨质疏松症、茶和咖啡”相关的关键词，系统检索了截至2024年11月5日发表在PubMed、Cochrane图书馆和Embase上的观察性研究。使用Stata软件14.0进行统计分析。当异质性较低（I²≤50%且P>0.1）时，使用固定效应模型。当异质性较大（I²>50%）时，使用随机效应模型。使用漏斗图和Egger回归检验评估发表偏倚。
结果
本荟萃分析纳入了14项观察性研究，共562838名参与者，这些研究发表于2008年至2024年之间。汇总分析表明，饮用咖啡与骨质疏松症风险降低显著相关（优势比[OR]=0.79，95%置信区间[CI]：0.73 - 0.84，I²=28.9%，P<0.05）。饮茶也显示出保护作用，骨质疏松症风险较低（OR=0.75，95%CI：0.62 - 0.91，I²=80.4%，P<0.05）。亚组分析显示，与低频饮用（每天少于一杯）相比，高频饮用咖啡（每天超过一杯）与骨质疏松症风险的更大降低相关（OR=0.83，95%CI：0.74 - 0.93，P=0.001），低频饮用未显示出统计学上的显著降低（OR=0.86，95%CI：0.68 - 1.07，P=0.171）。同样，与低频饮用（每周少于四次）相比，高频饮茶（每周超过四次）对骨质疏松症的保护作用略强（OR=0.82，95%CI：0.70 - 0.97，P=0.02）。
结论
本荟萃分析表明，长期饮用咖啡和茶与骨质疏松症风险降低相关。此外，在适度范围内较高的饮用频率似乎增强了对骨质疏松症的保护作用。
系统评价注册
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024612101，PROSPERO CRD42024612101。
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