Giugliano D, Ceriello A, Salvatore T, Paolisso G, D'Onofrio F, Lefèbvre P
J Clin Endocrinol Metab. 1987 May;64(5):944-8. doi: 10.1210/jcem-64-5-944.
To address the possibility that an abnormality in pancreatic beta-endorphin activity might contribute to abnormal insulin secretion in diabetes mellitus, we studied the effects of beta-endorphin infusion on islet function in diabetic patients. The iv infusion of human beta-endorphin at a dose of 0.5 mg/h for 2 h in type-2 non-insulin-dependent diabetic patients (n = 12) raised plasma insulin and glucagon levels and slightly but significantly lowered plasma glucose concentrations. beta-Endorphin infusion also resulted in reappearance of a clear-cut acute insulin response to glucose, while second phase insulin release was increased and glucose disposal accelerated. Acute insulin and glucagon responses to arginine were not increased by beta-endorphin, suggesting that the effect of the opioid on the B cells of the diabetic patients is specific for glucose. An intraislet abnormality of opioid peptides action and/or secretion may play a role in the disturbances of insulin secretion in patients with type-2 diabetes mellitus.
为了探讨胰腺β-内啡肽活性异常可能导致糖尿病患者胰岛素分泌异常的可能性，我们研究了β-内啡肽输注对糖尿病患者胰岛功能的影响。在2型非胰岛素依赖型糖尿病患者（n = 12）中，以0.5 mg/h的剂量静脉输注人β-内啡肽2小时，可提高血浆胰岛素和胰高血糖素水平，并轻微但显著降低血浆葡萄糖浓度。β-内啡肽输注还导致对葡萄糖的明显急性胰岛素反应再次出现，同时第二相胰岛素释放增加，葡萄糖处置加速。β-内啡肽并未增加对精氨酸的急性胰岛素和胰高血糖素反应，这表明阿片类药物对糖尿病患者B细胞的作用对葡萄糖具有特异性。胰岛内阿片肽作用和/或分泌的异常可能在2型糖尿病患者胰岛素分泌紊乱中起作用。
