Reid R L, Sandler J A, Yen S S
Metabolism. 1984 Mar;33(3):197-9. doi: 10.1016/0026-0495(84)90035-0.
Administration of human beta-endorphin (2.5 mg IV bolus) to three subjects with non-insulin-dependent diabetes mellitus (type II) induced prompt and simultaneous increments in the plasma concentrations of insulin and glucagon lasting up to 90 minutes. In contrast to the hyperglycemic response previously observed in normal subjects following beta-endorphin, these diabetics showed a progressive decline in plasma glucose throughout the study period. This disparity may be related to a relatively greater release of insulin and lesser rise in glucagon observed in diabetic subjects than in nondiabetic subjects. These preliminary findings suggest that further studies to elucidate the role of pancreatic beta-endorphin on glucoregulation may be rewarding.
给三名非胰岛素依赖型糖尿病（II型）患者静脉推注2.5毫克人β-内啡肽后，胰岛素和胰高血糖素的血浆浓度迅速同时升高，持续长达90分钟。与之前在正常受试者中观察到的β-内啡肽引起的高血糖反应相反，这些糖尿病患者在整个研究期间血浆葡萄糖呈逐渐下降趋势。这种差异可能与糖尿病患者比非糖尿病患者观察到的胰岛素释放相对更多和胰高血糖素升高幅度较小有关。这些初步发现表明，进一步研究以阐明胰腺β-内啡肽在血糖调节中的作用可能是有意义的。
