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择期切除无症状先天性肺气道畸形的最佳时机。

Optimal timing for elective resection of asymptomatic congenital pulmonary airway malformations.

机构信息

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

出版信息

J Pediatr Surg. 2018 May;53(5):1001-1005. doi: 10.1016/j.jpedsurg.2018.02.032. Epub 2018 Feb 10.

Abstract

PURPOSE

We sought to determine optimal timing for CPAM resection within the first year of life.

METHODS

We queried the National Surgical Quality Improvement Program pediatric database from 2012 to 2015 for elective CPAM resections on patients less than 1year of age. Patients were divided by age in months: 1-3 (n=57), 4-6 (n=135), and 6-12 (n=214). Patient operative variables and 30-day postoperative outcomes were compared.

RESULTS

A total of 406 patients were included with no differences in demographics or comorbidities. Median operative time increased with each older age category (115min, 152min, 163min, respectively; p<0.01). Thoracoscopic approach was less utilized in 1-3months (40.4%) compared to the older two age categories (65.9% and 69.6%, respectively; p<0.01). There were no differences by age in major complications, conversion to open, or readmissions. On multivariate analysis, ASA class≥3 (p<0.01) and prolonged operative time (p<0.01) were associated with a major complication. Furthermore, operations on patients aged 6-12months were associated with increased operative time (p<0.01) regardless of operative approach.

CONCLUSION

Elective CPAM resections are equally safe in patients 1-12months of age. Earlier resection including both open and thoracoscopic resection is associated with decreased operative time.

LEVEL OF EVIDENCE

IIc, Outcomes Research.

摘要

目的

我们旨在确定婴儿期内切除中央型气道肺隔离症(CPAM)的最佳时机。

方法

我们在 2012 年至 2015 年期间,通过国家外科质量改进计划儿科数据库,对年龄小于 1 岁且接受择期 CPAM 切除术的患者进行了查询。患者按月龄分为 1-3 个月(n=57)、4-6 个月(n=135)和 6-12 个月(n=214)。比较了患者的手术变量和术后 30 天的结果。

结果

共有 406 例患者纳入研究,其人口统计学和合并症均无差异。手术时间随年龄增长而逐渐增加(分别为 115 分钟、152 分钟和 163 分钟;p<0.01)。1-3 个月龄组的胸腔镜入路使用率(40.4%)明显低于后两个年龄组(分别为 65.9%和 69.6%;p<0.01)。不同年龄组之间主要并发症、中转开胸和再入院率无差异。多变量分析显示,ASA 分级≥3 级(p<0.01)和手术时间延长(p<0.01)与主要并发症相关。此外,无论手术方式如何,6-12 个月龄组的手术时间均较长(p<0.01)。

结论

1-12 个月龄的患者行 CPAM 切除术同样安全。早期切除,包括开放性和胸腔镜切除术,与手术时间缩短相关。

证据水平

IIc,结局研究。

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