链霉菌 120454 产生的具有抗菌活性的新型聚酮化合物马艾米林 B 的结构与生物合成。
Structure and biosynthesis of mayamycin B, a new polyketide with antibacterial activity from Streptomyces sp. 120454.
机构信息
State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing, 210023, China.
出版信息
J Antibiot (Tokyo). 2018 Jun;71(6):601-605. doi: 10.1038/s41429-018-0039-x. Epub 2018 Mar 7.
PMID:29515228
Abstract
Mayamycin B, a new antibacterial type II polyketide, together with its known congener mayamycin A, were isolated from Streptomyces sp. 120454. The structure of new compound was elucidated by extensive spectroscopic analysis and comparison with literature data. Sequencing and bioinformatics analysis revealed the biosynthetic gene cluster for mayamycins A and B.
摘要
马艾米霉素 B，一种新型的 II 型聚酮类抗生素，与已知的马艾米霉素 A 一起从链霉菌 120454 中分离得到。新化合物的结构通过广泛的光谱分析和与文献数据的比较得到阐明。测序和生物信息学分析揭示了马艾米霉素 A 和 B 的生物合成基因簇。
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