Kieler Wirkstoff-Zentrum (KiWiZ) , Leibniz Institute of Marine Sciences, Am Kiel-Kanal 44, Kiel, Germany.
J Nat Prod. 2010 Jul 23;73(7):1309-12. doi: 10.1021/np100135b.
A new benz[a]anthracene derivative called mayamycin (1) was identified in cultures of Streptomyces sp. strain HB202, which was isolated from the marine sponge Halichondria panicea and selected because of its profound antibiotic activity. The ability to produce aromatic polyketides was indicated by genetic analyses, demonstrating the presence of a type II polyketide synthase. The production of mayamycin (1) was induced by variation of the culture conditions. The structure of 1 was elucidated by HPLC-UV/MS and NMR spectroscopy. Mayamycin (1) exhibited potent cytotoxic activity against eight human cancer cell lines and showed activity against several bacteria including antibiotic-resistant strains.
一种名为马艾米霉素（1）的新型苯并[a]蒽衍生物在海洋海绵 Halichondria panicea 来源的链霉菌 sp. HB202 的培养物中被鉴定出来，该菌株因其具有强大的抗生素活性而被筛选出来。基因分析表明该菌株具有产生芳香聚酮化合物的能力，表明存在一种 II 型聚酮合酶。通过改变培养条件可以诱导马艾米霉素（1）的产生。通过 HPLC-UV/MS 和 NMR 光谱解析了 1 的结构。马艾米霉素（1）对八种人类癌细胞系表现出很强的细胞毒性活性，并对包括抗生素耐药株在内的几种细菌表现出活性。
