Piraino Frank F
Case Rep Oncol. 2017 Nov 28;10(3):1076-1084. doi: 10.1159/000484714. eCollection 2017 Sep-Dec.
A 74-year-old female was diagnosed with the autoimmune inflammatory disease temporal arteritis and treated with high and low doses of prednisone over a period of 6 years. During that time, she developed cancers of the lung and colon as well as a soft tumor mass on lumbar vertebrate L3. She also experienced a series of debilitating and disabling symptoms while on prednisone treatment. A temporal analysis of the association of prednisone therapy and immune markers to the successive appearance of the malignant tumors strongly suggests that in the absence of a functioning natural immune and surveillance system by treatment with the immune knockout drug prednisone, spontaneous, multiple independent mutations occurred in several sites in the organ systems of this patient. Over a period of time, these developed into malignant cancers, including a lung nodule which became cancerous 256 days later, as well as the cancers of the colon and a soft tumor mass on lumbar vertebrate L3.
一名74岁女性被诊断患有自身免疫性炎症疾病颞动脉炎，并在6年的时间里接受了高剂量和低剂量泼尼松治疗。在此期间，她患上了肺癌和结肠癌，以及腰椎L3处的一个软组织肿瘤。在服用泼尼松治疗期间，她还出现了一系列使人虚弱和致残的症状。对泼尼松治疗与免疫标志物和恶性肿瘤相继出现之间关联的时间分析强烈表明，由于使用免疫抑制药物泼尼松进行治疗，导致天然免疫和监测系统功能缺失，该患者器官系统的多个部位发生了自发的、多个独立的突变。随着时间的推移，这些突变发展成了恶性肿瘤，包括一个256天后癌变的肺结节，以及结肠癌和腰椎L3处的软组织肿瘤。
