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氨基脱氧葡萄糖糖化磷脂酰乙醇胺增强了脂质体的物理稳定性和选择性靶向能力。

Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes.

作者信息

Miyazawa Taiki, Kamiyoshihara Reina, Shimizu Naoki, Harigae Takahiro, Otoki Yurika, Ito Junya, Kato Shunji, Miyazawa Teruo, Nakagawa Kiyotaka

机构信息

Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-0845, Japan.

Department of Cell Biology, Division of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.

出版信息

R Soc Open Sci. 2018 Feb 14;5(2):171249. doi: 10.1098/rsos.171249. eCollection 2018 Feb.

DOI:10.1098/rsos.171249
PMID:29515844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5830733/
Abstract

Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing Amadori-glycated phosphatidylethanolamine exhibited significantly reduced negative membrane potential and demonstrated high cellular uptake.

摘要

由100%磷脂酰胆碱组成的脂质体表现出较差的膜融合、细胞摄取和选择性靶向能力。为了克服这些局限性，我们使用了阿马多里糖化磷脂酰乙醇胺，它普遍存在于动物体内且常见于食物中。我们发现，含有阿马多里糖化磷脂酰乙醇胺的脂质体表现出显著降低的负膜电位，并显示出高细胞摄取率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8abd/5830733/8bf11dc06fcf/rsos171249-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8abd/5830733/97f98a6f56b7/rsos171249-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8abd/5830733/8ccf5eabf5b3/rsos171249-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8abd/5830733/b461f8b8fa2b/rsos171249-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8abd/5830733/5aff6e05caf2/rsos171249-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8abd/5830733/85cba79af645/rsos171249-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8abd/5830733/a68d2188130c/rsos171249-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8abd/5830733/8bf11dc06fcf/rsos171249-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8abd/5830733/97f98a6f56b7/rsos171249-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8abd/5830733/8ccf5eabf5b3/rsos171249-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8abd/5830733/b461f8b8fa2b/rsos171249-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8abd/5830733/5aff6e05caf2/rsos171249-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8abd/5830733/85cba79af645/rsos171249-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8abd/5830733/a68d2188130c/rsos171249-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8abd/5830733/8bf11dc06fcf/rsos171249-g7.jpg

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Int J Nanomedicine. 2016 Jun 28;11:3009-22. doi: 10.2147/IJN.S107442. eCollection 2016.
2
Influence of Lipid Composition, pH, and Temperature on Physicochemical Properties of Liposomes with Curcumin as Model Drug.以姜黄素为模型药物时脂质组成、pH值和温度对脂质体物理化学性质的影响
J Oleo Sci. 2016;65(5):399-411. doi: 10.5650/jos.ess15229.
3
Therapeutic Applications of Curcumin Nanoformulations.
ACS Omega. 2018 Nov 30;3(11):15725-15733. doi: 10.1021/acsomega.8b01893. Epub 2018 Nov 19.
姜黄素纳米制剂的治疗应用
AAPS J. 2015 Nov;17(6):1341-56. doi: 10.1208/s12248-015-9811-z. Epub 2015 Sep 3.
4
Molecular basis of ligand recognition and transport by glucose transporters.葡萄糖转运蛋白识别和转运配体的分子基础。
Nature. 2015 Oct 15;526(7573):391-6. doi: 10.1038/nature14655. Epub 2015 Jul 15.
5
Curcumin, inflammation, and chronic diseases: how are they linked?姜黄素、炎症与慢性病：它们是如何关联的？
Molecules. 2015 May 20;20(5):9183-213. doi: 10.3390/molecules20059183.
6
Liposome and protein based stealth nanoparticles.脂质体和蛋白质基隐形纳米粒子。
Faraday Discuss. 2013;166:417-29. doi: 10.1039/c3fd00057e.
7
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Chem Sci. 2013 Jun;4(6):2319-2333. doi: 10.1039/C3SC22205E.
8
Current trends in the use of liposomes for tumor targeting.当前肿瘤靶向脂质体应用的趋势。
Nanomedicine (Lond). 2013 Sep;8(9):1509-28. doi: 10.2217/nnm.13.118.
9
Electrical properties of the red blood cell membrane and immunohematological investigation.红细胞膜的电学性质与免疫血液学研究。
Rev Bras Hematol Hemoter. 2011;33(4):297-301. doi: 10.5581/1516-8484.20110080.
10
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Adv Drug Deliv Rev. 2013 Jan;65(1):36-48. doi: 10.1016/j.addr.2012.09.037. Epub 2012 Oct 1.