Digestive Disease Institute, Cleveland Clinic, Weston.
Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville.
J Clin Gastroenterol. 2019 Mar;53(3):179-183. doi: 10.1097/MCG.0000000000001004.
The goal of this study is to examine the causes, type of adverse events (AE), and effects of elective intubation in outcomes associated with esophageal food impaction (EFI).
EFI is a gastrointestinal emergency requiring immediate medical attention.
Retrospective review of all EFI cases presenting at 3 large tertiary centers from October 1, 2011 to October 31, 2014 and all cases registered in the Clinical Outcome Research Initiative (CORI) database from January 1, 2000 to December 31, 2012. Statistical analysis compared health care utilization, AEs, and outcomes in patients with or without elective intubation.
A total of 214 cases presenting with EFI at our 3 referral hospitals and 4950 cases in the CORI database met inclusion criteria. Prevalence of structural disorders was similar in the Mayo Clinic and CORI datasets: 24.3% and 27.7% had strictures, and 3.8% and 2.5% had a tumor, respectively. AEs in the nonintubation group were 14.7% compared with 33.3% in the elective intubation group (P=0.003); however, 71.0% of these events were associated with EFI itself and not therapeutic procedure. Esophageal AEs were common (15.0%), followed by pulmonary and cardiovascular events with 3.0% and 1.4%, respectively. Severity of the AEs was influenced by the impaction-to-endoscopy time.
Prevalence of structural esophageal disorders was similar to previous smaller studies. Elective intubation was associated with increased AEs; however, this is felt to be because of the nature of EFI itself and not by therapeutic endoscopy. Prolonged impaction-to-endoscopy time was associated with severe AEs.
本研究旨在探讨食管食物嵌塞(EFI)相关不良事件(AE)的发生原因、AE 类型及择期插管的结局。
EFI 是一种需要立即就医的胃肠道急症。
回顾性分析 2011 年 10 月 1 日至 2014 年 10 月 31 日在 3 家大型三级医院就诊的所有 EFI 病例和 2000 年 1 月 1 日至 2012 年 12 月 31 日在临床结果研究倡议(CORI)数据库中登记的所有病例。统计学分析比较了有或无择期插管的患者的医疗保健利用、AE 和结局。
3 家转诊医院共 214 例 EFI 患者和 CORI 数据库中 4950 例患者符合纳入标准。梅奥诊所和 CORI 数据集的结构性疾病患病率相似:分别有 24.3%和 27.7%有狭窄,3.8%和 2.5%有肿瘤。非插管组的 AE 发生率为 14.7%,而择期插管组为 33.3%(P=0.003);然而,71.0%的这些事件与 EFI 本身而非治疗过程有关。食管 AE 很常见(15.0%),其次是肺部和心血管事件,发生率分别为 3.0%和 1.4%。AE 的严重程度受嵌塞至内镜检查时间的影响。
结构性食管疾病的患病率与之前的小样本研究相似。择期插管与 AE 增加相关;然而,这被认为是由于 EFI 本身的性质,而不是治疗性内镜检查。嵌塞至内镜检查时间延长与严重 AE 相关。