Mazzei J A, Torres J
Respiration. 1986;50 Suppl 2:313-7. doi: 10.1159/000195152.
A blind randomized cross-over comparative study of salbutamol and the combination fenoterol/ipratropium was carried out in 20 patients with mild to moderate bronchial asthma; clinical and functional serial parameters were evaluated. The combination was more effective than salbutamol in preventing crisis and incidence of cough and wheezing, and in the spirometric results. There were no significant differences in expectoration and the functional parameters improved not only in flow but also in volume. Pathogenesis is discussed.
对20例轻至中度支气管哮喘患者进行了沙丁胺醇与非诺特罗/异丙托溴铵联合用药的盲法随机交叉对照研究；评估了临床和功能系列参数。在预防发作、咳嗽和喘息的发生率以及肺功能测定结果方面，联合用药比沙丁胺醇更有效。咳痰方面无显著差异，功能参数不仅在流量方面得到改善，在容积方面也有所改善。对发病机制进行了讨论。
