Acker M A, Hammond R L, Mannion J D, Salmons S, Stephenson L W
Science. 1987 Apr 17;236(4799):324-7. doi: 10.1126/science.2951849.
Skeletal muscle ventricles (SMVs) were constructed from canine latissimus dorsi and connected to a totally implantable mock circulation device. The SMVs, stimulated by an implantable pulse generator, pumped continuously for up to 8 weeks in free-running beagle dogs. Systolic pressures produced by the SMVs, initially of 139 +/- 7.2 mmHg and after 1 month of continuous pumping of 107 +/- 7 mmHg, were comparable to normal physiologic pressures in the adult beagles (114 +/- 21 mmHg). After 2 weeks of continuous pumping, the mean stroke work of the SMVs was 0.4 X 10(6) ergs, a performance that compares favorably with the animal's cardiac ventricles. This study shows that canine skeletal muscle which has not received prior training or electrical conditioning can perform sustained work at the high levels needed for an auxiliary cardiovascular pump. It might be possible eventually to use such muscle pumps in humans to assist the failing circulation and to provide support in children with certain types of congenital heart defects.
骨骼肌心室（SMV）由犬的背阔肌构建而成，并与一个完全可植入的模拟循环装置相连。在可植入脉冲发生器的刺激下，骨骼肌心室在自由活动的比格犬体内持续泵血长达8周。骨骼肌心室产生的收缩压，最初为139±7.2 mmHg，持续泵血1个月后为107±7 mmHg，与成年比格犬的正常生理压力（114±21 mmHg）相当。持续泵血2周后，骨骼肌心室的平均每搏功为0.4×10⁶尔格，这一表现优于该动物的心脏心室。这项研究表明，未经预先训练或电调节的犬骨骼肌能够以辅助心血管泵所需的高水平进行持续工作。最终有可能在人类中使用这种肌肉泵来辅助衰竭的循环，并为患有某些类型先天性心脏缺陷的儿童提供支持。
