Abalos Edgardo, Oladapo Olufemi T, Chamillard Mónica, Díaz Virginia, Pasquale Julia, Bonet Mercedes, Souza Joao Paulo, Gülmezoglu A Metin
Centro Rosarino de Estudios Perinatales, Moreno 878, P6. (2000), Rosario, Argentina.
UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Reproductive Health and Research (RHR), World Health Organization, Avenue Appia 20, Geneva 27 CH-1211, Switzerland.
Eur J Obstet Gynecol Reprod Biol. 2018 Apr;223:123-132. doi: 10.1016/j.ejogrb.2018.02.026. Epub 2018 Feb 27.
Despite decades of research, the concept of normality in labour in terms of its progression and duration is not universal or standardized. However, in clinical practice, it is important to define the boundaries that distinguish what is normal from what is abnormal to enable women and care providers have a shared understanding of what to expect and when labour interventions are justified.
To synthesise available evidence on the duration of latent and active first stage and the second stage of spontaneous labour in women at low risk of complications with 'normal' perinatal outcomes.
PubMed, EMBASE, CINAHL, POPLINE, Global Health Library, and reference lists of eligible studies.
Observational studies and other study designs.
Four authors extracted data on: maternal characteristics; labour interventions; duration of latent first stage, active first stage, and second stage of labour; and the definitions of onset of latent and active first stage, and second stage where reported. Heterogeneity in the included studies precluded meta-analysis and data were presented descriptively.
Thirty-seven studies reporting the duration of first and/or second stages of labour for 208,000 women met our inclusion criteria. Among nulliparous women, the median duration of active first stage (when the starting reference point was 4 cm) ranged from 3.7-5.9 h (95th percentiles: 14.5-16.7 h). With active phase starting from 5 cm, the median duration was from 3.8-4.3 h (95th percentiles: 11.3-12.7 h). The median duration of second stage ranged from 14 to 66 min (95th percentiles: 65-138 min) and from 6 to 12 min (95th percentiles: 58-76 min) in nulliparous and parous women, respectively. Sensitivity analyses excluding first and second stage interventions did not significantly impact on these findings CONCLUSIONS: The duration of spontaneous labour in women with good perinatal outcomes varies from one woman to another. Some women may experience labour for longer than previously thought, and still achieve a vaginal birth without adverse perinatal outcomes. Our findings question the rigid limits currently applied in clinical practice for the assessment of prolonged first or second stage that warrant obstetric intervention.
尽管经过了数十年的研究,但分娩过程中的正常进展和持续时间的概念并非普遍适用或标准化。然而,在临床实践中,定义区分正常与异常的界限很重要,以便产妇和医护人员能够对预期情况以及何时进行分娩干预有共同的理解。
综合关于并发症风险低且围产期结局“正常”的产妇自发分娩潜伏期、活跃期第一产程和第二产程持续时间的现有证据。
检索了PubMed、EMBASE、CINAHL、POPLINE、全球健康图书馆以及符合条件研究的参考文献列表。
观察性研究和其他研究设计。
四位作者提取了以下数据:产妇特征;分娩干预措施;潜伏期第一产程、活跃期第一产程和第二产程的持续时间;以及潜伏期和活跃期第一产程开始的定义,以及第二产程开始的定义(如报告所述)。纳入研究的异质性排除了进行荟萃分析的可能性,数据以描述性方式呈现。
37项报告了208,000名妇女第一产程和/或第二产程持续时间的研究符合我们的纳入标准。在初产妇中,活跃期第一产程的中位持续时间(起始参考点为4厘米时)为3.7 - 5.9小时(第95百分位数:14.5 - 16.7小时)。活跃期从5厘米开始时,中位持续时间为3.8 - 4.3小时(第95百分位数:11.3 - 12.7小时)。初产妇和经产妇第二产程的中位持续时间分别为14至66分钟(第95百分位数:65 - 138分钟)和6至12分钟(第95百分位数:58 - 76分钟)。排除第一产程和第二产程干预措施的敏感性分析对这些结果没有显著影响。结论:围产期结局良好的产妇自发分娩持续时间因人而异。一些产妇的分娩时间可能比以前认为的更长,但仍能实现阴道分娩且无不良围产期结局。我们的研究结果质疑了目前临床实践中用于评估需要产科干预的第一产程或第二产程延长的严格界限。