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[遗传在缺血性心脏病患病率及其危险因素中的作用]

[Role of heredity in the prevalence of ischemic heart disease and its risk factors].

作者信息

Fomina R F, Zborovskiĭ E I, Baubinene A V, Domarkene S B, Ananasevich T A

出版信息

Ter Arkh. 1987;59(1):15-7.

PMID:2951886
Abstract

The relationship of heredity with CHD prevalence and the main risk factors (RF) was analyzed on the basis of the results of a primary cardiological screening of the male population aged 40 to 59 in Minsk and Kaunas (10012 persons). The results of the analysis were in favor of hereditary predisposition to CHD. The prevalence of CHD and the main RF in probands with aggravated heredity was much higher than that in probands with favorable heredity. CHD prevalence in the compared groups was 12.4 and 10.7%; SK 3.9 and 0.2%; cerebral stroke 1.6 and 0.6%, respectively. Statistically significant changes were also revealed in RF frequency: AH--32.6 and 27.1%; HCS--27.7 and 24.1%; EBM--16.6 and 13.8%; smoking--43.6 and 47.0%. Over 1/3 of all types of CHD and AH were found in the persons with hereditary predisposition to CHD on the maternal side with a tendency to CS.

摘要

根据对明斯克和考纳斯40至59岁男性人群(10012人)进行的首次心脏病学筛查结果,分析了遗传与冠心病患病率及主要危险因素(RF)之间的关系。分析结果支持冠心病存在遗传易感性。遗传因素严重的先证者中冠心病及主要危险因素的患病率远高于遗传因素良好的先证者。比较组中冠心病的患病率分别为12.4%和10.7%;收缩期高血压为3.9%和0.2%;脑卒中为1.6%和0.6%。危险因素频率也有统计学意义的变化:高血压——32.6%和27.1%;高胆固醇血症——27.7%和24.1%;心电图异常——16.6%和13.8%;吸烟——43.6%和47.0%。超过1/3的各类冠心病和高血压患者存在母系遗传易感性且有患脑卒中的倾向。

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