Ray-Offor E, Obiorah C C
Digestive Disease Unit, Oak Endoscopy Centre Port Harcourt; Departments of Surgery, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, Nigeria.
Department of Anatomical Pathology, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, Nigeria.
Niger J Clin Pract. 2018 Mar;21(3):375-379. doi: 10.4103/njcp.njcp_302_17.
Helicobacter pylori (H. pylori)-related atrophic gastritis transits through a sequential pathway of intestinal metaplasia, dysplasia to gastric cancer. Gastroscopy offers early detection, treatment and surveillance of gastric cancer.
This study aims to study the prevalence of H. pylori infection and evaluate precancerous lesions (PCLs) of the stomach.
This is a case controlled study of patients with dyspepsia undergoing gastroscopy at a referral endoscopy facility in Port Harcourt metropolis of Nigeria. The variables studied included demographics, clinical, endoscopic, and histopathologic findings. Statistical analysis of data was done using IBM SPSS Statistics for Windows, Version 20.0. (Armonk, NY, USA).
A total of 104 patients were included in the study. Age ranged from 20 to 80 years (mean 47.1 ± 14.4 years); 56 were males and 48 were females. H. pylori were detected in 40 (38.5%) mucosal biopsies. The prevalence of PCLs was: chronic atrophic gastritis 6.7% (7 cases); intestinal metaplasia 2.9% (3 cases); and dysplasia 5.8% (6 cases). There was no statistical significance in sex distribution of PCLs (P = 0.245).
There is a low prevalence of H. pylori in this metropolitan population. Mandatory multiple topographically targeted biopsies, even with normal mucosal appearance, at gastroscopy in addition to surveillance of PCL are recommended for early detection of gastric cancer.
幽门螺杆菌（H. pylori）相关的萎缩性胃炎会依次经历肠化生、发育异常，进而发展为胃癌。胃镜检查可实现胃癌的早期检测、治疗及监测。
本研究旨在探讨幽门螺杆菌感染的患病率，并评估胃部的癌前病变（PCLs）。
这是一项病例对照研究，研究对象为在尼日利亚哈科特港大都市一家转诊内镜检查机构接受胃镜检查的消化不良患者。所研究的变量包括人口统计学、临床、内镜及组织病理学检查结果。使用IBM SPSS Statistics for Windows 20.0版软件（美国纽约州阿蒙克）对数据进行统计分析。
本研究共纳入104例患者。年龄范围为20至80岁（平均47.1±14.4岁）；男性56例，女性48例。在40例（38.5%）黏膜活检样本中检测到幽门螺杆菌。癌前病变的患病率为：慢性萎缩性胃炎6.7%（7例）；肠化生2.9%（3例）；发育异常5.8%（6例）。癌前病变的性别分布无统计学意义（P = 0.24５）。
在这个大都市人群中，幽门螺杆菌的患病率较低。建议在胃镜检查时，即使黏膜外观正常，也需进行强制性的多部位靶向活检，并对癌前病变进行监测，以早期发现胃癌。
