Papazacharias Apostolos, Lozupone Madia, Barulli Maria Rosaria, Capozzo Rosa, Imbimbo Bruno P, Veneziani Federica, De Blasi Roberto, Nardini Marcello, Seripa Davide, Panza Francesco, Logroscino Giancarlo
Department of Basic Medical Science, Neuroscience and Sense Organs, Psychiatric Unit, University of Bari "Aldo Moro", Bari, Italy.
Department of Basic Medical Science, Neuroscience and Sense Organs, Neurodegenerative Disease Unit, University of Bari "Aldo Moro", Bari, Italy.
J Alzheimers Dis. 2017;55(3):973-979. doi: 10.3233/JAD-160860.
Bipolar disorder (BD) could represent a prodromal state of frontotemporal dementia (FTD). Two patients affected by lifelong BD with a progressive decline of cognitive functions, behavioral, and neurological signs, reached the early diagnosis of FTD before the age of 60. They were diagnosed as affected by primary progressive aphasia and FTD with parkinsonism, respectively. A diagnosis of FTD should therefore be taken into account, in case of unexpected cognitive and behavioral decline in patients with a long history of BD. Follow-up studies with genetic, neuropsychological, and neuroimaging markers of these BD/FTD patients could further explore some of the underlying association, opening new viable therapeutic options.
双相情感障碍（BD）可能是额颞叶痴呆（FTD）的前驱状态。两名终生患有双相情感障碍的患者出现认知功能、行为和神经体征的进行性衰退，在60岁之前被早期诊断为额颞叶痴呆。他们分别被诊断为原发性进行性失语和伴有帕金森综合征的额颞叶痴呆。因此，对于有长期双相情感障碍病史且出现意外认知和行为衰退的患者，应考虑额颞叶痴呆的诊断。对这些双相情感障碍/额颞叶痴呆患者进行基因、神经心理学和神经影像学标志物的随访研究，可能会进一步探索一些潜在关联，从而开辟新的可行治疗方案。
