Roswall Nina, Andersen Zorana Jovanovic, von Euler-Chelpin My, Vejborg Ilse, Lynge Elsebeth, Jensen Steen Solvang, Raaschou-Nielsen Ole, Tjønneland Anne, Sørensen Mette
Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.
Department of Public Health, Center for Epidemiology and Screening, University of Copenhagen, Copenhagen, Denmark.
Cancer Causes Control. 2018 May;29(4-5):399-404. doi: 10.1007/s10552-018-1021-4. Epub 2018 Mar 8.
Traffic is the most important source of community noise, and it has been proposed to be associated with a range of disease outcomes, including breast cancer. As mammographic breast density (MD) is one of the strongest risk factors for developing breast cancer, the present study investigated whether there is an association between residential exposure to traffic noise and MD in a Danish cohort.
We included women with reproductive and lifestyle information available from the Diet, Cancer, and Health cohort, who also participated in the Copenhagen Mammography Screening Programme (n = 5,260). Present and historical addresses from 1987 to 2011 were found in national registries, and traffic noise was modeled 5 years before mammogram. Analyses between residential traffic noise and MD were performed using logistic regression.
We found no association between residential road and railway noise exposure 5 years before mammogram, and having a mixed/dense versus a fatty mammogram, and no interaction with menopausal status, BMI, HRT use, and railway noise exposure, for analyses on road traffic noise.
The present study does not suggest an association between residential traffic noise exposure and subsequent MD in a cohort of middle-aged Danish women.
交通是社区噪音的最重要来源，并且有人提出交通噪音与一系列疾病后果相关，包括乳腺癌。由于乳腺钼靶密度（MD）是患乳腺癌的最强风险因素之一，本研究调查了丹麦队列中居住环境暴露于交通噪音与MD之间是否存在关联。
我们纳入了饮食、癌症和健康队列中提供了生殖和生活方式信息且还参加了哥本哈根乳腺钼靶筛查项目的女性（n = 5260）。在国家登记处找到了1987年至2011年的当前和历史住址，并在乳腺钼靶检查前5年对交通噪音进行了建模。使用逻辑回归分析居住交通噪音与MD之间的关系。
在乳腺钼靶检查前5年，我们未发现居住道路和铁路噪音暴露与乳腺钼靶为混合型/致密型而非脂肪型之间存在关联，并且在道路交通噪音分析中，未发现与绝经状态、体重指数、激素替代疗法使用情况以及铁路噪音暴露存在相互作用。
本研究未表明丹麦中年女性队列中居住交通噪音暴露与随后的MD之间存在关联。
