头颈部癌患者远处转移接受特定治疗后总生存期得到改善。
Improved overall survival in head and neck cancer patients after specific therapy of distant metastases.
作者信息
Schulz Dominik, Wirth Markus, Piontek Guido, Knopf Andreas, Straube Christoph, Pigorsch Steffi, Combs Stephanie E, Pickhard Anja
机构信息
Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Department of Otolaryngology Head and Neck Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany.
出版信息
Eur Arch Otorhinolaryngol. 2018 May;275(5):1239-1247. doi: 10.1007/s00405-018-4920-9. Epub 2018 Mar 8.
PURPOSE
While metastases directed therapy for oligometastatic disease is recommended in different cancer entities, the treatment of solitary metastases in head and neck squamous cell carcinoma (HNSCC) patients is not clearly defined.
METHODS
A retrospective analysis was performed on data from 143 HNSCC patients treated between 2001 and 2016 in a tertiary university hospital. Clinical factors and outcome were measured using the median survival of patients receiving metastases specific therapy in comparison with matched control patients.
RESULTS
In 37 patients, distant metastases were treated specifically with either surgery and/or stereotactic ablative radiotherapy and had with 23.97 months a more than three times higher median survival than 10 untreated matched controls with potentially treatable distant metastases (7.07 months).
CONCLUSIONS
Our retrospective analysis demonstrates a significant survival benefit for HNSCC patients who received a specific therapy regarding distant metastasis irrespective of localization as compared to a matched control cohort.
目的
虽然针对寡转移疾病的转移灶定向治疗在不同癌症实体中均有推荐，但头颈部鳞状细胞癌（HNSCC）患者孤立转移灶的治疗尚无明确界定。
方法
对2001年至2016年间在一所三级大学医院接受治疗的143例HNSCC患者的数据进行回顾性分析。通过接受转移灶特异性治疗的患者与匹配对照患者的中位生存期来衡量临床因素和预后。
结果
37例患者接受了手术和/或立体定向消融放疗等针对远处转移灶的特异性治疗，其23.97个月的中位生存期比10例未接受治疗、具有潜在可治疗远处转移灶的匹配对照患者（7.07个月）高出三倍多。
结论
我们的回顾性分析表明，与匹配对照队列相比，接受针对远处转移灶特异性治疗的HNSCC患者无论转移灶位于何处均有显著的生存获益。
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