居住在意大利中部的 1016 名志愿者尿液中四种多环芳烃代谢物和可替宁水平的测定。
Levels of urinary metabolites of four PAHs and cotinine determined in 1016 volunteers living in Central Italy.
机构信息
Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Research Area of Monte Porzio Catone (RM), INAIL Research, Via di Fontana Candida 1, 00040 Monteporzio Catone, Rome, Italy.
Master Degree Course in Analytical Chemistry, Rome University Sapienza, Rome, Italy.
出版信息
Environ Sci Pollut Res Int. 2018 Oct;25(29):28772-28779. doi: 10.1007/s11356-018-1650-x. Epub 2018 Mar 8.
Polycyclic aromatic hydrocarbons (PAH) are products of the incomplete combustion of organic materials, and exposure of the general population to PAH is ubiquitous. They are also present in tobacco smoke. Some PAH are classified as carcinogens. Urine samples from 747 non-smoking and 269 smoking subjects living in the same area of Central Italy were analyzed in order to determine reference values for PAHs exposure of a general population. The concentration of cotinine, urinary metabolite of nicotine was also measured in these samples in order to classify the subjects as smokers or not. The median concentration and 50th percentile in females was higher than in males for all metabolites; 1- and 2-hydroxynaphtalene (1-OHNAP and 2-OHNAP) and 1-hydroxypyrene (1-OHPy), are significantly higher in smokers; on the other side 3-hydroxybenzo[a]pyrene (3-OHBaPy) and 6-hydroxynitropyrene (6-OHNPy) do not correlate with the cotinine concentration.
多环芳烃（PAH）是有机物质不完全燃烧的产物，一般人群普遍接触到 PAH。它们也存在于烟草烟雾中。一些 PAH 被归类为致癌物质。对居住在意大利中部同一地区的 747 名不吸烟和 269 名吸烟的受试者的尿液样本进行了分析，以确定一般人群对 PAH 暴露的参考值。还测量了这些样本中尼古丁代谢物可替宁的浓度，以便将受试者分类为吸烟者或非吸烟者。对于所有代谢物，女性的中位数和 50 百分位数均高于男性；1-和 2-羟基萘（1-OHNAP 和 2-OHNAP）和 1-羟基芘（1-OHPy）在吸烟者中显着更高；另一方面，3-羟基苯并[a]芘（3-OHBaPy）和 6-羟基硝基芘（6-OHNPy）与可替宁浓度无关。
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