Department of Family Medicine, Chang Gung Memorial Hospital, Chiayi 613, Taiwan.
Department of Pulmonary Disease and Critical Care, Chang Gung Memorial Hospital, Yunlin 638, Taiwan.
Int J Environ Res Public Health. 2022 Jan 26;19(3):1362. doi: 10.3390/ijerph19031362.
The association between the biomarkers of environmental exposure, oxidative stress, and health-related behaviors in community residents living in an endemic viral hepatitis area and near petrochemical industrial complexes remains unclear. From a health promotion perspective, healthcare providers must know what to do for residents concerned about their health and living environment, especially for individual-level and modifiable risk factors. Therefore, we aimed to explore the factors associated with urinary 1-hydroxypyrene (1-OHP) and malondialdehyde (MDA).
A community-based, cross-sectional study was conducted between July 2018 and February 2019 in western coastal Yunlin County, Taiwan. All participants lived within a 10 km radius of a large petrochemical complex and did not work in the factory. This study was conducted with the local hospital through annual community health screening. Biological samples were collected and biomarkers determined and quantified in the central laboratory of the collaborating hospital.
A total of 6335 adult residents completed the study. The mean age was 47.7 (SD = 16) years. Out of the total population, 56.4% were female, 30.1% had metabolic syndrome (MetS), and 16.8% and 14.3% had hepatitis B virus antigen (HBsAg) and hepatitis C virus antibody (anti-HCV) positivity, respectively. The median 1-OHP and MDA level was 0.11 and 0.9 μg/g creatinine with an interquartile range of 0.07-0.18, and 0.4-1.5, respectively. The MDA levels correlated with specific diseases. The multivariable ordinal logistic regression model revealed that female sex, smoking, betel nut use, HBsAg, and anti-HCV positivity were associated with higher 1-OHP levels. In men, MetS was associated with higher 1-OHP levels and regular exercise with lower 1-OHP levels. High MDA levels were associated with smoking, betel nut users, HBsAg, and anti-HCV positivity.
The findings highlight the importance of initiating individualized health promotion programs for residents near petrochemical factories, especially for adults with substance-use and cardiometabolic risk factors. Furthermore, it is crucial to provide further treatment to patients with viral hepatitis.
在病毒性肝炎流行地区和靠近石化工业综合体的社区居民中，环境暴露生物标志物、氧化应激与健康相关行为之间的关系尚不清楚。从健康促进的角度来看，医疗保健提供者必须了解针对关注自身健康和生活环境的居民应该做些什么，尤其是针对个体层面和可改变的危险因素。因此，我们旨在探讨与尿 1-羟基芘（1-OHP）和丙二醛（MDA）相关的因素。
本研究于 2018 年 7 月至 2019 年 2 月在台湾西部沿海云林县进行了一项基于社区的横断面研究。所有参与者均居住在大型石化综合体 10 公里半径范围内，且不在工厂工作。该研究通过当地医院进行，借助于年度社区健康筛查。在合作医院的中心实验室采集生物样本并对生物标志物进行检测和定量。
共有 6335 名成年居民完成了研究。平均年龄为 47.7（SD=16）岁。在总人口中，56.4%为女性，30.1%患有代谢综合征（MetS），16.8%和 14.3%分别为乙型肝炎病毒抗原（HBsAg）和丙型肝炎病毒抗体（抗-HCV）阳性。1-OHP 和 MDA 的中位数水平分别为 0.11 和 0.9μg/g 肌酐，四分位距分别为 0.07-0.18 和 0.4-1.5。MDA 水平与特定疾病相关。多变量有序逻辑回归模型显示，女性、吸烟、嚼槟榔、HBsAg 和抗-HCV 阳性与较高的 1-OHP 水平相关。在男性中，MetS 与较高的 1-OHP 水平相关，而定期运动与较低的 1-OHP 水平相关。高 MDA 水平与吸烟、嚼槟榔者、HBsAg 和抗-HCV 阳性相关。
研究结果强调了为石化厂附近的居民启动个体化健康促进计划的重要性，尤其是针对有物质使用和心血管代谢危险因素的成年人。此外，为病毒性肝炎患者提供进一步的治疗至关重要。
