Gnezditskaia E V, Bukhova V P, Zakharova N A, Malkina L A
Biull Eksp Biol Med. 1987 Apr;103(4):447-9.
It was established by immunofluorescence that lactoferrin, one of the heteroorganic thymus antigens, can stimulate the expression of Fc mu and Fcj receptors on thymus lymphocytes. The stimulating effect of lactoferrin on T mu cells is more pronounced with the level of these cells in the thymus being low. Its effect on Tj cells seems independent of their level in the thymus and may be related to their precursor differentiation. It can be assumed that one of the functions of lactoferrin in the thymus is to influence the process of differentiation of T mu and Tj cells and to regulate their level in the thymus. Lactoferrin, like other heteroorganic thymus antigens, may take part in the functional maturation of different subpopulations of thymocytes, including T mu and Tj thymus cells.
通过免疫荧光法证实，乳铁蛋白作为一种异种有机胸腺抗原，能够刺激胸腺淋巴细胞上Fcμ和Fcγ受体的表达。当胸腺中Tμ细胞水平较低时，乳铁蛋白对其刺激作用更为明显。它对Tγ细胞的作用似乎与其在胸腺中的水平无关，可能与它们的前体分化有关。可以推测，乳铁蛋白在胸腺中的功能之一是影响Tμ和Tγ细胞的分化过程，并调节它们在胸腺中的水平。乳铁蛋白与其他异种有机胸腺抗原一样，可能参与包括Tμ和Tγ胸腺细胞在内的不同亚群胸腺细胞的功能成熟。
