柴油机废气与肺癌——成为国际癌症研究机构第 1 组致癌物之后。
Diesel Exhaust and Lung Cancer-Aftermath of Becoming an IARC Group 1 Carcinogen.
机构信息
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
出版信息
Am J Epidemiol. 2018 Jun 1;187(6):1149-1152. doi: 10.1093/aje/kwy036.
Abstract
The International Agency for Research on Cancer reclassified diesel exhaust from Group 2A (probably carcinogenic to humans) to Group 1 (carcinogenic to humans) in 2012. Since then, reevaluation and reanalysis of 2 major studies (Diesel Exhaust in Miners Study and Trucking Industry Particle Study) that were influential to the International Agency for Research on Cancer evaluation have replicated the original findings and demonstrated the suitability of these epidemiologic data for the quantitative risk assessment needed to set safe exposure limits in occupational and outdoor ambient environments. The challenge now is to protect the workers and general populations in urban areas from the carcinogenicity of diesel exhaust.
摘要
国际癌症研究机构于 2012 年将柴油废气从 2A 组（可能对人类致癌）重新分类为 1 组（对人类致癌）。此后，对两项对国际癌症研究机构评估有影响的主要研究（矿工柴油废气研究和卡车运输业粒子研究）进行了重新评估和重新分析，这些研究复制了最初的发现，并证明了这些流行病学数据适合进行定量风险评估，以确定职业和户外环境中安全的暴露限值。现在的挑战是保护城市地区的工人和一般人群免受柴油废气的致癌性影响。
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