Attah Reuben, Kaur Kamaljeet, Reilly Christopher A, Deering-Rice Cassandra E, Kelly Kerry E
Department of Chemical Engineering, University of Utah, Salt Lake City, UT, United States of America.
Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, United States.
J Aerosol Sci. 2025 Jan;183. doi: 10.1016/j.jaerosci.2024.106473. Epub 2024 Sep 24.
Fine particulate matter (PM) is associated with numerous adverse health effects, including pulmonary and cardiovascular diseases and premature death. Significant contributors to ambient PM include combustion particles and secondary organic aerosols (SOA). Combustion particles enter the atmosphere and undergo an aging process that changes their shape and composition, but there is limited study on the health effects of combustion particle aging and interactions with SOA. This study aimed to understand how biological responses to combustion particles would be affected by atmospheric aging and interaction with anthropogenic SOA. Fresh combustion particles underwent photochemical aging in a potential aerosol mass (PAM) oxidation flow reactor and interacted with SOA produced by the oxidation of toluene vapor in the PAM reactor. Photochemical aging and SOA interactions lead to significant changes in the PAH content and oxidative potential of the particle. Photochemical aging and SOA interactions also affected the biological responses, such as the inflammatory response and CYP1A1 induction of the particles in monoculture and coculture cells. These findings highlight the significance of photochemical aging and SOA interactions on the composition and cellular responses of combustion particles.
细颗粒物（PM）与众多不良健康影响相关，包括肺部和心血管疾病以及过早死亡。环境PM的重要来源包括燃烧颗粒和二次有机气溶胶（SOA）。燃烧颗粒进入大气并经历老化过程，这会改变它们的形状和成分，但关于燃烧颗粒老化及其与SOA相互作用对健康影响的研究有限。本研究旨在了解燃烧颗粒的生物反应如何受到大气老化以及与人为SOA相互作用的影响。新鲜燃烧颗粒在潜在气溶胶质量（PAM）氧化流动反应器中进行光化学老化，并与PAM反应器中甲苯蒸汽氧化产生的SOA相互作用。光化学老化和SOA相互作用导致颗粒的多环芳烃含量和氧化潜力发生显著变化。光化学老化和SOA相互作用还影响了生物反应，例如在单培养和共培养细胞中颗粒的炎症反应和CYP1A1诱导。这些发现突出了光化学老化和SOA相互作用对燃烧颗粒组成和细胞反应的重要性。
