Kulcke Axel, Holmer Amadeus, Wahl Philip, Siemers Frank, Wild Thomas, Daeschlein Georg
Diaspective Vision GmbH, Strandstraße 15, D-18233 Am Salzhaff, Germany.
Diaspective Vision GmbH, Strandstrasse 13, D-18233 Am Salzhaff, Germany.
Biomed Tech (Berl). 2018 Oct 25;63(5):519-527. doi: 10.1515/bmt-2017-0145.
Worldwide, chronic wounds are still a major and increasing problem area in medicine with protracted suffering of patients and enormous costs. Beside conventional wound treatment, for instance kinds of oxygen therapy and cold plasma technology have been tested, providing an improvement in the perfusion of wounds and their healing potential, but these methods are unfortunately not sufficiently validated and accepted for clinical practice to date. Using hyperspectral imaging technology in the visible (VIS) and near infrared (NIR) region with high spectral and spatial resolution, perfusion parameters of tissue and wounds can be determined. We present a new compact hyperspectral camera which can be used in clinical practice. From hyperspectral data the hemoglobin oxygenation (StO2), the relative concentration of hemoglobin [tissue hemoglobin index (THI)] and the so-called NIR-perfusion index can be determined. The first two parameters are calculated from the VIS-part of the spectrum and represent the perfusion of superficial tissue layers, whereas the NIR-perfusion index is calculated from the NIR-part representing the perfusion in deeper layers. First clinical measurements of transplanted flaps and chronic ulcer wounds show, that the perfusion level can be determined quantitatively allowing sensitive evaluation and monitoring for an optimization of the wound treatment planning and for validation of new treatment methods.
在全球范围内，慢性伤口仍然是医学领域中一个日益严重的主要问题，给患者带来长期痛苦并造成巨大成本。除了传统的伤口治疗方法外，例如各种氧疗和冷等离子体技术都已进行过测试，这些方法能改善伤口的灌注及其愈合潜力，但遗憾的是，到目前为止这些方法在临床实践中尚未得到充分验证和认可。利用具有高光谱和空间分辨率的可见（VIS）和近红外（NIR）区域的高光谱成像技术，可以确定组织和伤口的灌注参数。我们展示了一种可用于临床实践的新型紧凑型高光谱相机。从高光谱数据中，可以确定血红蛋白氧合（StO2）、血红蛋白的相对浓度[组织血红蛋白指数（THI）]以及所谓的近红外灌注指数。前两个参数是根据光谱的可见光部分计算得出的，代表浅表组织层的灌注情况，而近红外灌注指数是根据代表深层灌注的近红外部分计算得出的。对移植皮瓣和慢性溃疡伤口的首次临床测量表明，可以定量确定灌注水平，从而进行敏感评估和监测，以优化伤口治疗方案并验证新的治疗方法。
